A unique metabolism of inorganic arsenic in native Andean women

Vahter, Marie; Concha, Gabriela; Nermell, Barbro; Nilsson, Ricky; Dulout, Fernando Noel; Natarajan, A.T.

doi:10.1016/s0014-2999(95)80104-9

Cited by 29 publications

(44 citation statements)

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“…It has been speculated previously that ethnicity might be a determinant factor in arsenic methylation efficiency. A report in 1995 showed that native Andean women had overall lower %uMMA in comparison to populations from Europe, Japan and USA (Vahter et al , 1995). Our study populations were only classified as Hispanic or Non-hispanic by self-report.…”

Section: Discussionmentioning

confidence: 99%

Association between body mass index and arsenic methylation efficiency in adult women from southwest U.S. and northwest Mexico

Gomez‐Rubio

Roberge

Arendell

et al. 2011

Toxicology and Applied Pharmacology

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Human arsenic methylation efficiency has been consistently associated with arsenic-induced disease risk. Interindividual variation in arsenic methylation profiles is commonly observed in exposed populations, and great effort has been put into the study of potential determinants of this variability. Among the factors that have been evaluated, body mass index (BMI) has not been consistently associated with arsenic methylation efficiency, however an underrepresentation of the upper BMI distribution was commonly observed in these studies. This study investigated potential factors contributing to variations in the metabolism of arsenic, with specific interest in the effect of BMI where more than half of the population was overweight or obese. We studied 624 adult women exposed to arsenic in drinking water from three independent populations. Multivariate regression models showed that higher BMI, arsenic (+3 oxidation state) methyltransferase (AS3MT) genetic variant 7388, and higher total urinary arsenic, were significantly associated with low percentage of urinary arsenic excreted as monomethylarsonic acid (%uMMA) or high ratio between urinary dimethylarsinic acid and uMMA (uDMA/uMMA); while AS3MT genetic variant M287T was associated with high %uMMA and low uDMA/uMMA. The association between BMI and arsenic methylation efficiency was also evident in each of the three populations when studied separately. This strong association observed between high BMI and low %uMMA and high uDMA/uMMA underscores the importance of BMI as a potential arsenic-associated disease risk factor, and should be carefully considered in future studies associating human arsenic metabolism and toxicity.

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Section: Discussionmentioning

confidence: 99%

Association between body mass index and arsenic methylation efficiency in adult women from southwest U.S. and northwest Mexico

Gomez‐Rubio

Roberge

Arendell

et al. 2011

Toxicology and Applied Pharmacology

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“…66 Another point worth stressing is that diVerences in methylating capacity are probably due to methyltransferase gene polymorphism as suggested by Vahter et al 33 Inorganic As in urine could, therefore, be more closely related to the most critical eVect (cancer) than other biological indicators of the element.…”

Section: Discussionmentioning

confidence: 99%

“…[22][23][24][25][26][27][28] Drinking water may be a relevant source of iAs in some geographical areas, and this natural kind of water pollution has been related to skin alterations, cardiovascular diseases, and cancer. [29][30][31][32][33][34][35] The absorption of As from food, water, and air explains the presence, in variable amounts, of the element in the urine of the general population. The urinary concentrations of As vary considerably, between 5 and 50 µg/l, and therefore groups from diVerent countries could be distinguished on this basis.…”

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confidence: 99%

Biological monitoring of occupational exposure to inorganic arsenic.

et al. 1999

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Objectives-This study was undertaken to assess reliable biological indicators for monitoring the occupational exposure to inorganic arsenic (iAs), taking into account the possible confounding role of arsenicals present in food and of the element present in drinking water. Methods-51 Glass workers exposed to As trioxide were monitored by measuring dust in the breathing zone, with personal air samplers. Urine samples at the end of work shift were analysed for biological monitoring. A control group of 39 subjects not exposed to As, and eight volunteers who drank water containing about 45 µg/l iAs for a week were also considered. Plasma mass spectrometry (ICP-MS) was used for the analysis of total As in air and urine samples, whereas the urinary As species (trivalent, As Conclusions-To avoid the eVect of As from sources other than occupation on urinary species of the element, in particular on DMA, it is proposed that urinary As 3 +As 5 may an indicator for monitoring the exposure to iAs. For concentrations of 10 µg/m 3 the current environmental limit for iAs, the limit for urinary As 3 +As 5 was calculated to be around 5 µg/l, even if the wide variation of values needs critical evaluation and application of data. The choice of this indicator might be relevant also from a toxicological point of view. Trivalent arsenic is in fact the most active species and its measure in urine could be the best indicator of some critical eVects of the element, such as cancer. (Occup Environ Med 1999;56:825-832)

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“…In general, urine consists of 10-30% iAs, 10% MMA and 60-80% DMA, which are commonly used as a measure of methylation capacity or efficiency. However, indigenous people in the north of Argentina only have a few percent of MMA in urine, while people in Taiwan have 20-30% [69].…”

Section: Humansmentioning

confidence: 99%

Metabolism and the Paradoxical Effects of Arsenic: Carcinogenesis and Anticancer

Cui¹,

Kobayashi²,

Akashi³

et al. 2008

CMC

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Arsenic, a known human carcinogen, can induce tumors of the skin, urinary bladder, liver and lung etc.. On the other hand, arsenic is also a novel promising anticancer agent, and can be used effectively to treat acute promyelocytic leukemia (APL) and some other tumors. These paradoxical effects of arsenic not only result from direct or indirect influences on the genetic and epigenetic levels, but are also closely correlated with unique arsenic metabolism. This article reviews our recent studies as well as other reports on arsenic metabolism and epigenetic changes of DNA methylation during its metabolism. We also summarize the clinical use of arsenic trioxide (As2O3) to date and discuss new therapeutic strategies such as concurrent arsenic-radiation therapy to achieve local tumor control and enhance the radiosensitivity of solid tumors.

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A unique metabolism of inorganic arsenic in native Andean women

Cited by 29 publications

References 0 publications

Association between body mass index and arsenic methylation efficiency in adult women from southwest U.S. and northwest Mexico

Association between body mass index and arsenic methylation efficiency in adult women from southwest U.S. and northwest Mexico

Biological monitoring of occupational exposure to inorganic arsenic.

Metabolism and the Paradoxical Effects of Arsenic: Carcinogenesis and Anticancer

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