A Unique Presentation of Metastatic Gallbladder Carcinoma

Abstract

Gallbladder carcinoma can be challenging to diagnose and treat and usually leads to poor outcome, due to its aggressive nature and the nonspecific clinical presentation at early stage. We describe an interesting case of a 60-year-old female who presented with stage 3 appendiceal carcinoma after appendectomy was performed outside hospital. Further imaging workup demonstrated enlarged ovarian cysts and porcelain gallbladder. Upon exploration, she was found to have carcinomatosis and we proceeded with cytoreductive surgery (CRS) and hyperthermic intraperitoneal therapy (HIPEC). Final pathology demonstrated carcinoma from gallbladder primary.

Cholecystopathia chronica calcarea (Porcelain gall bladder): A case report from Nepal

“…A porcelain gallbladder is an unusual cholecystopathological condition in which the gallbladder wall gets calcified either completely or partially. During this process, it can become brittle and bluish, resulting in a “porcelain” like appearance [ 1 , 2 , 7 , 8 , 10 ].…”

“…It has been documented that females outnumber males (5:1), ranging in age from the 3rd decade to the 7th decade [ 5 ], with an incidence ranging from 0.06 to 0.8% and a risk of malignancy varying from 5% to 22% [ 2 , 6 ]. As it is a potentially pre-malignant condition with a plausibility of malignant transformation, cholecystectomy remains the favored surgical treatment of choice [ 2 , 7 , 8 ].…”

Metastatic Gallbladder Carcinoma to the Ovary Presenting As Small Bowel Obstruction

“…Carcinoma of the gallbladder is an incidental finding in 1% of patients undergoing cholecystectomy due to presenting cholelithiasis [ 1 ]. Gallbladder cancer is a rare and aggressive malignancy accounting for 1.2% of all global cancer diagnoses [ 2 ]. Most patients are diagnosed at a more advanced stage with poor clinical outcomes due to the absence of symptoms or non-specific clinical presentation and lack of effective screening diagnostic methods.…”