A Unique Presentation of Pulmonary Langerhans Cell Histiocytosis

Srivatsav, Varun; Tallon, Kelsey

doi:10.1016/j.rmcr.2022.101635

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…In early stages, differential diagnoses include lung metastasis, miliary tuberculosis, silicosis, sarcoidosis, GPA, and respiratory bronchiolitis (RB)-ILD [32]. Later in the disease, principal differential diagnoses include UIP, centrilobular emphysema, LAM, and LIP [32,[99][100][101]. Typical PCLH micronodules centrilobular location allows clinicians to differentiate it from sarcoidosis and silicosis, which also predominate at the Differential diagnosis depends on whether the nodular or cystic change is the dominant feature.…”

Section: Diagnosismentioning

confidence: 99%

Noninfectious Granulomatous Lung Disease: Radiological Findings and Differential Diagnosis

Lassandro,

Picchi,

Corvino

et al. 2024

JPM

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Granulomatous lung diseases (GLDs) are a heterogeneous group of pathological entities that can have different clinical presentations and outcomes. Granulomas are histologically defined as focal aggregations of activated macrophages, Langerhans cells, and lymphocytes, and may form in the lungs when the immune system cannot eliminate a foreign antigen and attempts to barricade it. The diagnosis includes clinical evaluation, laboratory testing, and radiological imaging, which especially consists of high-resolution computed tomography. bronchoalveolar lavage, transbronchial needle aspiration or cryobiopsy, positron emission tomography, while genetic evaluation can improve the diagnostic accuracy. Differential diagnosis is challenging due to the numerous different imaging appearances with which GLDs may manifest. Indeed, GLDs include both infectious and noninfectious, and necrotizing and non-necrotizing granulomatous diseases and the imaging appearance of some GLDs may mimic malignancy, leading to confirmatory biopsy. The purposes of our review are to report the different noninfectious granulomatous entities and to show their various imaging features to help radiologists recognize them properly and make an accurate differential diagnosis.

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Section: Diagnosismentioning

confidence: 99%

Noninfectious Granulomatous Lung Disease: Radiological Findings and Differential Diagnosis

Lassandro,

Picchi,

Corvino

et al. 2024

JPM

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Lymphangioleiomyomatosis and Langerhans cell histiocytosis - two case reports from our practice

et al. 2022

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Introduction. Lymphangioleiomyomatosis (LAM) and pulmonary Langerhans cell histiocytosis (PLCH) are the most common pulmonary cystic diseases. Although they differ in pathogenesis, they share several features. The aim of this paper is to present the similarities and differences between these diseases, as well as to describe two cases from our practice. Outlines of cases. The patient with LAM (43 y.) has pulmonary changes detected during regular examination within the underlying disease - tuberous sclerosis. Four years after starting therapy with everolimus she is still respiratory asymptomatic, a slight radiological deterioration of cystic changes is registered, the diffusion capacity is declining (for 12%). The second patient (23 y.) was admitted due to bilateral radiological lung changes and symptoms in the form of dry cough, quick fatigue and chest pain. Pathohistological examination of the transbronchial biopsy showed numerous large-core histiocytes, immunohistochemically positive for CD1a and S100, so it has been concluded that it is Langerhans cell histiocytosis. Cessation of smoking was advised. The follow-up examinations show withdrawal of symptoms and an orderly finding of lung function, chest HRCT indicates slight regression of changes. In the meantime, the patient gave birth to a healthy child, the pregnancy and prenatal period went smoothly. Conclusion. These diseases are extremely rare and in cooperation with other specialties should be distinguished from diseases that mimic lung cysts.

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A Unique Presentation of Pulmonary Langerhans Cell Histiocytosis

Cited by 2 publications

References 17 publications

Noninfectious Granulomatous Lung Disease: Radiological Findings and Differential Diagnosis

Noninfectious Granulomatous Lung Disease: Radiological Findings and Differential Diagnosis

Lymphangioleiomyomatosis and Langerhans cell histiocytosis - two case reports from our practice

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