A unique vaccine for control of fertility and therapy of advanced‐stage terminal cancers ectopically expressing human chorionic gonadotropin

Abstract

Human chorionic gonadotropin (hCG) appears soon after fertilization of the egg and plays a critical role in implantation of the embryo leading to the beginning of pregnancy. Vaccines developed against hCG prevent pregnancy without impairment of ovulation and disturbance of menstrual regularity. A new recombinant vaccine hCGβ-LTB has been developed that is highly immunogenic in various strains of mice and intended for the control of fertility in women. An additional use of this vaccine is likely to be treatment of advanced-stage cancers that ectopically express hCG.

Contraceptive Vaccines: Review

“…hCG'nin inaktivasyonunun dişi fizyolojisinde, ovulasyonda, seks steroid hormon üretiminde ve menstrüel regülasyonda hiçbir olumsuz etkiye yol açmadığı gösterilmiştir; bu yüzden hCG immünokontrasepsiyonda iyi bir hedef olarak ön plana çıkmaktadır. 74,75 hCG'nin asıl olarak fertilizasyonu değil implantasyonu bloke ettiği gerçeği aslında hCG bazlı aşıların kontrasetif aşı değil doğum kontrol aşısı olarak anılmasını gerektirmektedir. 4 hCG'nin β-subuniti 145 amino asit uzunluğundadır ve 30 amino asit uzunluğunda karboksi terminal peptid (CTP) uzantısına sahiptir.…”

The Recombinant Vaccine against Human Chorionic Gonadotropin goes on Combined Immunogenicity, Safety and Efficacy Clinical Trials

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The above mentioned vaccine in the form made in the laboratory was expensive and time consuming. In order to render it amenable to industrial production, we made a genetically engineered version of the vaccine, in which beta subunit of hCG was linked to B subunit of heat labile enterotoxin of E. coli as carrier [4]. Figure 1 shows the sequence of nucleotides of this recombinant vaccine.The recombinant vaccine adsorbed on alhydrogel with adjuvant autoclaved Mycobacterium indicus pranii (MIP), induced fairly high anti-hCG antibodies in not only BalbC, but also in other genetic strains of mice [5,6].

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