A universal stimuli-responsive biosensor for disease biomarkers through their cysteine residues: A proof of concept on carcinoembryonic antigen (CEA) biomarker

Gholami, Mahnaz D.; Nihal, Serena; Liu, Qian; Sarfo, Daniel K.; Sonar, Prashant; Izake, Emad L.

doi:10.1016/j.snb.2023.134208

Cited by 5 publications

(1 citation statement)

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“… 5 Since stimuli-responsive materials adopt different behaviors depending on the conditions, desired properties can be programmed. As a result, stimuli-responsive materials hold considerable promise in applications ranging from disease detection 6 to sustainable building environment development. 7 …”

Section: Introductionmentioning

confidence: 99%

Soft Materials with Time-Programmed Changes in Physical Properties through Lyotropic Phase Transitions Induced by pH-Changing Reactions

Bowley,

Liu,

Adams

et al. 2024

ACS Appl. Mater. Interfaces

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We present the development of time-programmable functional soft materials. The materials undergo reversible phase transitions between lyotropic phases with different topologies and symmetries, which in turn have very different physical properties: viscosity, diffusion, and optical transparency. Here, this behavior is achieved by combining pHresponsive lyotropic phases made from the lipid monoolein doped with 10% oleic acid, with chemical reactions that have well-defined controllable kinetics: autocatalytic urea−urease and methyl formate hydrolysis, which increase and decrease pH, respectively. In this case, we use small-angle X-ray scattering (SAXS) and optical imaging to show temporally controlled transitions between the cloudy hexagonal phase, which is a two-dimensional (2D) array of cylindrical inverse micelles, and the transparent, highly viscous three-dimensional (3D) bicontinuous cubic phases. By combining these into a single reaction mixture where the pH increases and then decreases again, we can induce a sequential transformation cycle from hexagonal to cubic and back to hexagonal over several hours. The sample therefore changes from cloudy to transparent and back again as a proof-of-concept demonstration for a wider range of soft materials with time-programmable changes in physical properties.

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Section: Introductionmentioning

confidence: 99%