A UPLC–MSMS method for the analysis of olanzapine in serum—with particular emphasis on drug stability testing

Perinatal maternal depression, antidepressant use and infant sleep outcomes: Exploring cross-lagged associations in a pregnancy cohort study

“…Blood was centrifuged and the plasma stored at -80°C within one hour of collection. All samples were analyzed with liquid chromatography with mass spectrometry or tandem mass spectrometry, with methods described previously (Andreassen et al, 2015;Reis et al, 2009). The assay levels for each antidepressant type were standardized by relating the concentrations measured to the middle of the therapeutic range for the same drug (Hiemke et al, 2011) so that concentration levels were comparable across the variety of applied antidepressants.…”

Determination of atypical antipsychotics in human plasma by UPLC-UV with polystyrene nanofibers as a solid-phase extraction sorbent

“…Most studies have shown that its stability depends on sample matrix and physical storage conditions such as light exposure and temperature. 34 …”

UPLC Technique in Pharmacy—An Important Tool of the Modern Analyst

“…UPLC methods are used to separate mixtures and identify many chemical compounds (in addition to those listed above, also amino acids, nucleic acids, proteins, steroids, etc.) [183], check the purity of manufactured drugs to ensure product quality [73], monitor the kinetics of chemical reactions (including the synthesis of new structures of potential therapeutic importance) [184], study physicochemical properties, i.e., lipophilicity (alongside the commonly used TLC method) [185,186], perform isomer analysis [187], or complete stability tests in changing environmental conditions [188]. Maximized pressure, minimal lag, and fast injections enable very fast cycle times while maximizing peak yields.…”