A Urinary Detergent and Urolithiasis

Charlton, Clive

doi:10.1111/j.1464-410x.1989.tb05245.x

Cited by 6 publications

(4 citation statements)

References 17 publications

(15 reference statements)

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“…The observation in this study associating higher urinary fibrinolytic activity with lower meat consumpition is clearly of interest and will be pursued further. If this observation is subsequently confirmed and reduction in meat intake is observed to increase urinary fibrinolytic activity, the risk of further stone formation may be reduced if the hypothesis of Charlton (1989) is true. In addition, if urinary fibrinolysis reflects circulating fibrinolytic activity, it will also have positive implications regarding thrombogenic cardiovascular disease.…”

Section: Discussionmentioning

confidence: 93%

“…This argument was developed more fully in a recent review (Charlton, 1989). As supporting evidence, observations were cited that macromolecules in stone formers' urine are larger than in normal individuals (Drach et al, 1982).…”

mentioning

confidence: 95%

“…Furthermore, there is evidence that circulating triglycerides and cholesterol may be raised in stone formers (Rao and Blacklock, unpublished results), while decreased plasminogen activator (fibrinolytic Accepted for publication 3 May 1990 activity) has been observed under these circumstances (Cilas-Greenwalt et al, 1984). Charlton (1989) suggested that a new approach to the: treatment of recurrent stone disease would be to try to increase urinary fibrinolytic activity. Since any benefits of this would become apparent only after prolonged treatment, we felt it was crucial to re-examine the urinary fibrinolytic activity in stone formers and controls.…”

mentioning

confidence: 99%

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Do stone rormers nave Lower urinary Fibrinolytic Activity than Controls?

Margetts¹,

Barker²,

Kavanagh³

et al. 1990

British Journal of Urology

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A comparison of urinary fibrinolytic activity between 31 stone formers and 50 controls failed to demonstrate any significant difference and so failed to confirm an earlier independent observation. This may be due to methodological and design differences between the 2 studies, but does suggest reservations about the significance of lowered urinary fibrinolytic activity as a risk factor for renal stone disease. Dietary information from those taking part in the study suggests that a reduction of meat intake by stone formers might be associated with increased urinary fibrinolytic activity. This might account for the discrepancy between the 2 studies, in which case this observation could be of significance.

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Section: Discussionmentioning

confidence: 93%

mentioning

confidence: 95%

mentioning

confidence: 99%

See 1 more Smart Citation

Do stone rormers nave Lower urinary Fibrinolytic Activity than Controls?

Margetts¹,

Barker²,

Kavanagh³

et al. 1990

British Journal of Urology

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“…Due to their surface activity, they can be used as stabilizers of colloidal sus pensions [10], and hence, aescin (a saponin) has been pro posed to avoid secondary aggregation (formation of aggre gates as a consequence of crystal-crystal collisions) in uric acid urolithiasis. Because the presence of saponins in practically all herb infusions to which some antilithiasic properties were assigned [11], we decided to study the effects of two saponins (aescin and glycyrrhinic acid), at therapeutic quantities, on the heterogeneous nucleation and development of COM crystals.…”

Section: Discussionmentioning

confidence: 99%

Study of the Effects of Different Substances on the Early Stages of Papillary Stone Formation

Gráses

García-Ferragut²,

Costa-Bauzà³

et al. 1996

Nephron

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We have studied the early stages of calcium oxalate monohydrate (COM) crystallization, mainly heterogeneous nucleation, on fixed particles. Experiments were performed using a flow system that closely simulates the human renal conditions related to COM heterogeneous nucleation. The effects of citrate, phytate, aescin and glycyrrhinic acid in the COM heterogeneous nucleation on different solid surfaces as calcium phosphate, a mixture of mucin and calcium phosphate and wax were studied. The presence of citrate at normal urinary concentrations (1.85 · 10^-3M) totally inhibited the development of COM crystals only on the most hydrophobic assayed material (wax). Saponins (aescin and glycyrrhinic acid) only exhibited important inhibitory effects of COM crystallization on the hydrophobic wax substrate but in no case the formation of COM crystals was totally prevented. Phytate exerted the most remarkable effects on the heterogeneous nucleation of COM crystals, thus, when it was present at 1.43 · 10^-7M, it totally prevented the development of COM crystals on the three assayed solid substrates.

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