A useful predictor in machine perfusion preservation for kidney transplantation from non–heart-beating donors

Matsuno, Naoto; Kozaki, Koichi; Degawa, Hisakazu; Narumi, Y; Suzuki, Nobuhiro; Kikuchi, Kenjiro; Uchiyama, M; Kubota, K; Sakurai, E; Kozaki, M; Nagao, Toshiyasu

doi:10.1016/s0041-1345(99)00919-7

Cited by 31 publications

(36 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Of these, nine [52][53][54][55][56][57][58][59][60] were published between 1974 and 1981, reporting seven studies of the use of perfusate flow characteristics and biochemical markers. A further 17 papers published since 1993 have been identified, [61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77] reporting 11 studies. Details of all studies are given in Table 4.…”

Section: Papers Identified For Reviewmentioning

confidence: 99%

The clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heart-beating and non-heart-beating donors

Wight

Chilcott²,

Holmes³

et al. 2003

Health Technol Assess

125

View full text Add to dashboard Cite

Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email.Paying by official purchase order You can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. HTAThe clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heartbeating and non-heart-beating donors This report should be referenced as follows:Wight J, Chilcott J, Holmes M, Brewer N. The clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heart-beating and non-heart-beating donors. Health Technol Assess 2003;7(25). Health Technology Assessment is indexed in Criteria for inclusion in the HTA monograph seriesReports are published in the HTA monograph series if (1) they have resulted from work commissioned for the HTA Programme, and (2) they are of a sufficiently high scientific quality as assessed by the referees and editors.Reviews in Health Technology Assessment are termed 'systematic' when the account of the search, appraisal and synthesis methods (to minimise biases and random errors) would, in theory, permit the replication of the review by others. O2Objectives: To evaluate the clinical and costeffectiveness of machine perfusion (MP) compared to cold storage (CS), as a means of preserving kidneys prior to transplantation. Transplantation of kidneys from both heart-beating donors (HBDs) and non-heartbeating donors (NHBDs) is considered. Finally to review whether the use of MP can allow valid testing of kidney viability prior to transplantation. Data sources: Fifteen electronic bibliographic databases were searched. The reference lists of relevant articles and sponso...

show abstract

Section: Papers Identified For Reviewmentioning

confidence: 99%

The clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heart-beating and non-heart-beating donors

Wight

Chilcott²,

Holmes³

et al. 2003

Health Technol Assess

125

View full text Add to dashboard Cite

show abstract

“…Perfusion characteristics of kidneys preserved by machine pulsatile perfusion are used to evaluate organ viability (8,9). In particular, a high resistive index may be associated with poor graft function as it reflects renal vasoconstriction.…”

Section: Introductionmentioning

confidence: 99%

Redox-Active Iron Released During Machine Perfusion Predicts Viability of Ischemically Injured Deceased Donor Kidneys

Vries

Snoeijs

Bonsdorff

et al. 2006

American Journal of Transplantation

View full text Add to dashboard Cite

Redox-active iron, catalyzing the generation of reactive oxygen species, has been implicated in experimental renal ischemia-reperfusion injury. However, in clinical transplantation, it is unknown whether redoxactive iron is involved in the pathophysiology of ischemic injury of non-heart-beating (NHB) donor kidneys. We measured redox-active iron concentrations in perfusate samples of 231 deceased donor kidneys that were preserved by machine pulsatile perfusion at our institution between May 1998 and November 2002 using the bleomycin detectable iron assay. During machine pulsatile perfusion, redox-active iron was released into the preservation solution. Ischemically injured NHB donor kidneys had significantly higher perfusate redox-active iron concentrations than heartbeating (HB) donor kidneys that were not subjected to warm ischemia (3.9 ± 1.1 vs. 2.8 ± 1.0 lmol/L, p = 0.001). Moreover, redox-active iron concentration was an independent predictor of post-transplant graft viability (odds ratio 1.68, p = 0.01) and added predictive value to currently available donor and graft characteristics. This was particularly evident in uncontrolled NHB donor kidneys for which there is the greatest uncertainty about transplant outcomes. Therefore, perfusate redox-active iron concentration shows promise as a novel viability marker of NHB donor kidneys.

show abstract

“…They showed that kidneys with the highest perfusion flow rates were superior in all 5 fields. 18 Further research by the group confirmed the correlation between flow rates and immediate function and primary nonfunction. [18][19] Both studies showed high rates of acute tubular necrosis, but this resolved faster in kidneys with higher flow rates.…”

Section: Machine Perfusion Pressuresmentioning

confidence: 88%

“…18 Further research by the group confirmed the correlation between flow rates and immediate function and primary nonfunction. [18][19] Both studies showed high rates of acute tubular necrosis, but this resolved faster in kidneys with higher flow rates. [18][19] The importance of flow rates was highlighted further by Balupuri and associates, with a case of immediate nonfunction in a graft with acceptable perfusate biomarkers and perfusion pressures, but a low flow rate (26 mL/min/100 g).…”

Section: Machine Perfusion Pressuresmentioning

confidence: 88%

“…[18][19] Both studies showed high rates of acute tubular necrosis, but this resolved faster in kidneys with higher flow rates. [18][19] The importance of flow rates was highlighted further by Balupuri and associates, with a case of immediate nonfunction in a graft with acceptable perfusate biomarkers and perfusion pressures, but a low flow rate (26 mL/min/100 g). Of the 13 transplants, this was the only one to not work, suggesting that flow rates may be one of the most important variables.…”

Section: Machine Perfusion Pressuresmentioning

confidence: 99%

See 1 more Smart Citation

Advances in Machine Perfusion Graft Viability Assessment in Kidney, Liver, Pancreas, Lung, and Heart Transplant

Balfoussia

Yerrakalva²,

Hamaoui³

et al. 2012

Exp Clin Transplant

View full text Add to dashboard Cite

A useful predictor in machine perfusion preservation for kidney transplantation from non–heart-beating donors

Cited by 31 publications

References 2 publications

The clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heart-beating and non-heart-beating donors

The clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heart-beating and non-heart-beating donors

Redox-Active Iron Released During Machine Perfusion Predicts Viability of Ischemically Injured Deceased Donor Kidneys

Advances in Machine Perfusion Graft Viability Assessment in Kidney, Liver, Pancreas, Lung, and Heart Transplant

Contact Info

Product

Resources

About