A V1-type receptor for mediating the neurohypophysial hormone-induced ACTH release in trout pituitary

Pierson, Patricia; Guibbolini, Marielle; Lahlou, B.

doi:10.1677/joe.0.1490109

Cited by 32 publications

(17 citation statements)

References 21 publications

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“…The results of our AVT injections revealed increased secretion of S into sea lamprey plasma. The involvement of neurohypophysial hormones and other neuroendocrine hormones in the regulation of corticotropic functions in fishes has been known, including the AVT and CRH/isotocin actions on ACTH secretion from pituitary of goldfish and rainbow trout (Baker et al, 1996;Fryer et al, 1985;Pierson et al, 1996), AVT and thyrotropin releasing hormone (TRH) actions on ACTH release in goldfish (Fryer et al, 1985;Lederis et al, 1994) and gilthead sea bream (Rotllant et al, 2000). The participation of the neurohypophysial hormones in direct stimulation of corticosteroid has been reported in amphibians (Larcher et al, 1992a) and mammals (Aguilera et al, 2008), indicating that the interplay between different hormonal axes or endocrine factors is widely present in vertebrates, including fishes, as summarized by Bernier and Klaren (2009).…”

Section: Discussionmentioning

confidence: 99%

Regulation of a putative corticosteroid, 17,21-dihydroxypregn-4-ene,3,20-one, in sea lamprey, Petromyzon marinus

Roberts

Didier

Rai

et al. 2014

General and Comparative Endocrinology

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a b s t r a c tIn higher vertebrates, in response to stress, the hypothalamus produces corticotropin-releasing hormone (CRH), which stimulates cells in the anterior pituitary to produce adrenocorticotropic hormone (ACTH), which in turn stimulates production of either cortisol (F) or corticosterone (B) by the adrenal tissues. In lampreys, however, neither of these steroids is present. Instead, it has been proposed that the stress steroid is actually 17,21-dihydroxypregn-4-ene-3,20-dione (11-deoxycortisol; S). However, there have been no studies yet to determine its mechanism of regulation or site of production. Here we demonstrate that (1) intraperitoneal injections of lamprey-CRH increase plasma S in a dose dependent manner, (2) intraperitoneal injections of four lamprey-specific ACTH peptides at 100 lg/kg, did not induce changes in plasma S concentrations in either males or females; (3) two lamprey-specific gonadotropin-releasing hormones (GnRH I and III) and arginine-vasotocin (AVT), all at single doses, stimulated S production as well as, or to an even greater extent than CRH; (4) sea lamprey mesonephric kidneys, in vitro, converted tritiated 17a-hydroxyprogesterone (17a-P) into a steroid that had the same chromatographic properties (on HPLC and TLC) as S; (5) kidney tissues released significantly more immunoassayable S into the incubation medium than gill, liver or gonad tissues. One interpretation of these results is that the corticosteroid production of the sea lamprey, one of the oldest extant vertebrates, is regulated through multiple pathways rather than the classical HPI-axis. However, the responsiveness of this steroid to the GnRH peptides means that a reproductive rather than a stress role for this steroid cannot yet be ruled out.

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Section: Discussionmentioning

confidence: 99%

Regulation of a putative corticosteroid, 17,21-dihydroxypregn-4-ene,3,20-one, in sea lamprey, Petromyzon marinus

Roberts

Didier

Rai

et al. 2014

General and Comparative Endocrinology

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“…Several investigators have utilized this approach in amphibians (Larcher et al 1992, Butlen et al 1993) and fishes (Pang & Furspan 1984, Guibbolini & Lahlou 1990, Uchiyama & Murakami 1994, Pierson et al 1996, Guibbolini et al 2000. The present study is the first attempt to characterize pharmacologically the neurohypophysial peptide receptors in the gill respiratory cells of a marine fish.…”

Section: Pharmacological Characterization Of Receptorsmentioning

confidence: 94%

Neurohypophysial hormone regulation of Cl- secretion: physiological evidence for V1-type receptors in sea bass gill respiratory cells in culture

Guibbolini¹,

Avella²

2003

Journal of Endocrinology

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Neurohypophysial hormone receptors were studied in primary cultures of sea bass (Dicentrarchus labrax) gill respiratory-like cells grown on permeable supports. This preparation was previously shown to provide a functional model for investigating the hormonal regulation of Cl secretion.Under control conditions, the cultured monolayered epithelium had a short-circuit current (I SC ) of 3·5 1·1 µA cm 2 . This current had previously been identified as an active Cl secretion. The addition of increasing concentrations of the fish neurohypophysial hormones, arginine vasotocin (AVT) or isotocin (IT), elicited a concentration-dependent stimulation of the I SC . Maximal increases of 60·9 12·1% and 117·7 28·0% above the basal I SC value were obtained for 10 7 M AVT and IT respectively. Half-maximal effects were obtained for 3·1 10 9 M AVT and for 1·4 10 9 M IT. Mucosal application of 1·0 mM diphenylalamine-2-carboxylic acid (a specific blocker of Cl channels) after serosal addition of 5 10 8 M AVT or IT inhibited not only the basal but also the stimulated current, revealing a correlation with a hormone-dependent Cl transport.Specific V1 or V2 receptor analogues of vasopressin (mammalian hormone) were used to characterize the type of neurohypophysial hormone receptors pharmaco- ]-vasopressin used at the same concentration had no significant effect. In contrast, similar experiments carried out in the presence of 10 8 M IT showed that both antagonists significantly reduced the IT-stimulated Cl secretion, with the efficiency of the V1 receptor antagonist being significantly greater than that of the V2.This study provides evidence for neurohypophysial hormone control of Cl secretion in fish cultured gill respiratory cells. It suggests that on a physiological basis the hormonal effect is shared by the two peptides present in fish neurohypophysis (AVT and IT), acting by means of two distinct, although pharmacologically similar, V1-type receptors (according to the mammalian classification). These specific receptors are expected to play an important role in controlling ion homeostasis in seawater fish.

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“…Several investigators used this approach in amphibians (Larcher et al 1992, Butlen et al 1993) and fishes (Pang & Furspan 1984, Guibbolini & Lahlou 1990, Uchiyama & Murakami 1994, Pierson et al 1996. The present study is the first attempt to characterize the neurohypophysial hormone receptor in fish hepatocytes by means of artificial analogues.…”

Section: Discussionmentioning

confidence: 92%

“…also exist in fish, namely in eel liver (Moon & Mommsen 1990) and in trout kidney (Perrott et al 1993), although the concentrations of hormone used in their experiments were high (D max between 10 -6 -10 -5 M). Our previous work on peripheral vasotocin receptors in lower vertebrates emphasized the 'V 1 ' feature of these receptors in such distinct organs as trout pituitary and gill (Guibbolini & Lahlou 1987, Guibbolini & Lahlou 1990, Pierson et al 1996. Recently, in the teleost fish Catostomus commersoni, the molecular structure of the vasotocin receptor was established by Mahlmann et al (1994) and that of the isotocin receptor by Hausmann et al (1995).…”

Section: Discussionmentioning

confidence: 99%

Neurohypophysial hormone receptors and second messengers in trout hepatocytes

Guibbolini

Pierson²,

Lahlou³

2000

Journal of Endocrinology

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Neurohypophysial hormone receptors and second messengers were studied in trout (Oncorhynchus mykiss) hepatocytes. Arginine vasotocin (AVT) and isotocin (IT) elicited a concentration-dependent inhibition of cAMP accumulation in the presence of 5 10 -8 M glucagon (maximal effect for 4·5 10 -7 M and 1·4 10 -7 M, half-maximal effect for 2·1 10 -8 M and 0·7 10 -8 M, AVT and IT respectively). The effect of glucagon was inhibited up to 90% by AVT and 80% by IT. While AVT inhibited (up to 50%) the basal cAMP production, IT had no such action.Specific V 1 or V 2 analogues (with reference to vasopressin in mammals) were used for pharmacological characterization of the type of neurohypophysial hormone receptor involved in this inhibition. The ]-vasopressin had no such effect. In this particular case, maximal and half-maximal effects of the V 1 antagonist were obtained for 2·3 10 -6 M and 1·2 10 -6 M respectively.Changes in intracellular calcium content were measured using the fluorescent probe FURA-2/AM. AVT and IT elicited a concentration-dependent increase in Ca 2+ accumulation. The comparison of the effect of 10 -8 M agonists versus AVT showed the following order of potency: AVT=IT>V 1 agonist>V 2 agonist. The V 1 antagonist reversed the AVT-induced Ca 2+ accumulation whereas the V 2 antagonist had no such effect.These results are taken as evidence for the presence in trout hepatocytes of neurohypophysial hormone receptors functionally close to the V 1a -type linked to cAMP production and Ca 2+ mobilization.

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A V1-type receptor for mediating the neurohypophysial hormone-induced ACTH release in trout pituitary

Cited by 32 publications

References 21 publications

Regulation of a putative corticosteroid, 17,21-dihydroxypregn-4-ene,3,20-one, in sea lamprey, Petromyzon marinus

Regulation of a putative corticosteroid, 17,21-dihydroxypregn-4-ene,3,20-one, in sea lamprey, Petromyzon marinus

Neurohypophysial hormone regulation of Cl- secretion: physiological evidence for V1-type receptors in sea bass gill respiratory cells in culture

Neurohypophysial hormone receptors and second messengers in trout hepatocytes

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