A validated LC-MS/MS method for determination of antiviral prodrug molnupiravir in human plasma and its application for a pharmacokinetic modeling study in healthy Egyptian volunteers

Recent analytical methodologies for the determination of anti-covid-19 drug therapies in various matrices: a critical review

“…The accuracy, precision, selectivity, and sensitivity of the established method were all confirmed. 51…”

“…The accuracy, precision, selectivity, and sensitivity of the established method were all conrmed. 51 2.2.3 Analysis in both pharmaceutical dosage forms and biological matrices. Saraya et al have developed a novel, green, inexpensive, and solvent-free method (ultra-puried water was used for dissolution and dilution) for the determination of MLP in tablets and plasma samples.…”

New validated liquid chromatography‐tandem mass spectrometry method for the determination of Dacomitinib in human plasma and its application to a pharmacokinetic study

“…Hence the present work aimed to develop an LC‐tandem MS (LC‐MS/MS) method for the determination of Dacomitinib (Figure 1) in K 2 EDTAin human plasma. The validated assay has been successfully applied to the pharmacokinetic and bioavailability study of Dacomitinib in human plasma [14–19]. The results of this study will demonstrate the suitability of the developed method for the estimation of drugs in human blood plasma with adequate accuracy and precision (Figure 3).…”

Green adherent spectrophotometric determination of molnupiravir based on computational calculations; application to a recently FDA-approved pharmaceutical dosage form

“…Since MLP has recently entered the market, the development of validated analytical methods is recommended to enable accurate determination and quality control approach of MPL in different analytical laboratories. Previous work has proposed the use of LC-MS /MS [39] , [40] and HPLC [41] for the determination of MLP, recommending the disposal of organic wastes that have a negative impact on the environment. Spectrophotometry represents a simple continental tool for quantitative analysis of drugs.…”

“…Although LC-MS /MS [39] , [40] and HPLC [41] have been reported for the determination of MLP in the presence of its active metabolite and in the presence of various antiviral drugs. Unfortunately, the use of organic solvents in LC-MS /MS and HPLC can lead to environmental contamination and potential health risks to analysts if improperly disposed of.…”