A Validated Liquid Chromatographic Method for the Determination of Solifenacin Succinate (Urinary Antispasmodic) in Tablets

Objective: To develop and validate simple, rapid and sensitive spectrophotometric method for the assay of four antimuscarinic antagonists, namely oxybutynin (OXB), solifenacin (SOL), tolterodine (TOL) and fesoterodine (FES) in bulk and pharmaceutical formulations.Methods: The proposed method is based on the reaction of the selected drugs with eriochrome cyanine R (ECR) in buffered aqueous solution at pH 1.0. The formed ion-pair complexes were extracted with dichloromethane and measured quantitatively with maximum absorption at 464 nm. All variables that affect on color intensity such as pH, buffer volume and concentration of ECR and extractive solvents were studied and optimized.Results: The calibration graphs were linear over the concentration range of 4–24, 4–32, 4–32 and 2–22 mg/ml for OXB, SOL, TOL and FES, respectively. The stoichiometry of the reaction was found to be 1:1 in all cases. Molar absorptivity values were found to be 2.043×104, 1.856×104, 1.798×104 and 2.856×104 l/mol/cm for OXB, SOL, TOL and FES, respectively. Excipients which used as an additive in commercial formulations did not interfere in the analysis.Conclusion: The developed method was successfully applied to determine OXB, SOL, TOL and FES in pharmaceutical preparations. The developed method can be used for quality control and routine analysis where time, cost effectiveness and high specificity of analytical technique are of great importance.

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Development of commercially feasible and Cost-effective tablet of Solifenacin succinate that can be compounded into an oral suspension

Manohari¹,

Seshadri²,

Reddy³

et al. 2022

RJPT

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In this research an attempt was made to develop and evaluate a commercially feasible and cost-effective tablet and oral suspension of Solifenacin Succinate. In international market, Solifenacin Succinate is available in both tablet and oral suspension dosage form. In Indian market, only tablet dosage form is available. Hence it was decided to make a formulation of Solifenacin Succinate that will not only be used as an oral solid dosage form in the form of tablet but also can be readily converted to oral suspension by extemporaneous means. A simple direct blending process was followed using limited excipients to make the end product cost-effective. The finalized product was comparable to the international brand product with respect to physico-chemical attributes, drug release and stability. The prepared tablet was made into an oral suspension using Ora-Plus® and Ora-Sweet® and the compounded suspension showed good palatability, organoleptics, chemical and microbial stability.

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A Validated Liquid Chromatographic Method for the Determination of Solifenacin Succinate (Urinary Antispasmodic) in Tablets

Cited by 3 publications

References 8 publications

Highly selective analysis of glipizide as an antidiabetic drug in urine samples using HPLC-DAD technique via magnetic nanocomposites (Fe3O4@SiO2@tryptophan)

Highly selective analysis of glipizide as an antidiabetic drug in urine samples using HPLC-DAD technique via magnetic nanocomposites (Fe3O4@SiO2@tryptophan)

Extractive-Spectrophotometric Determination of Some Antimuscarinic Antagonist in Tablet Formulations Using Eriochrome Cyanine R

Development of commercially feasible and Cost-effective tablet of Solifenacin succinate that can be compounded into an oral suspension

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