A Validated RP-HPLC–DAD Method for Analyzing Flavonoids in Caatinga Brazilian Green Propolis from Mimosa tenuiflora Produced by Apis mellifera

Son, Ninh The; Ribeiro, Victor Pena; Groppo, Milton; Linh, Nguyen Ngoc; Bastos, Jairo Kenupp

doi:10.1007/s43450-024-00604-w

Rev. Bras. Farmacogn.

2024

DOI: 10.1007/s43450-024-00604-w

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A Validated RP-HPLC–DAD Method for Analyzing Flavonoids in Caatinga Brazilian Green Propolis from Mimosa tenuiflora Produced by Apis mellifera

Ninh The Son,

Victor Pena Ribeiro,

Milton Groppo

et al.

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2024

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Cited by 1 publication

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Chemical Characterization and Antimicrobial Activity of Green Propolis from the Brazilian Caatinga Biome

Aldana-Mejía,

Ribeiro,

Katragunta

et al. 2024

Plants

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Green propolis, particularly from the unique flora of the Brazilian Caatinga biome, has gained significant interest due to its diverse chemical composition and biological activities. This study focuses on the chemical characterization and antimicrobial evaluation of Caatinga green propolis. Twelve compounds were isolated through different chromatographic techniques, including flavanones (naringenin, 7-O-methyleriodictyol, sakuranetin), flavones (hispidulin, cirsimaritin), flavonols (quercetin, quercetin-3-methyl ether, kaempferol, 6-methoxykaempferol, viscosine, penduletin), and one chalcone (kukulkanin B). Using liquid chromatography–quadrupole time-of-flight tandem mass spectrometry (LC-QToF-MS), a total of 55 compounds excluding reference standards were tentatively identified, which include flavonoids, phenolic acids derivatives, and alkaloids, with flavonols, flavanones, and flavones being predominant. Antimicrobial testing against pathogens revealed that the crude extract exhibited low inhibitory activity, against Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus faecium (VRE) (IC50: 148.4 and 120.98 µg/mL, respectively). Although the isolated compounds showed limited individual activity, a fraction containing sakuranetin and penduletin (Fraction 8) exhibited moderated activity against Cryptococcus neoformans (IC50: 47.86 µg/mL), while a fraction containing quercetin and hispidulin showed moderated activity against VRE (IC50: 16.99 µg/mL). These findings highlight the potential application of Caatinga green propolis as an antimicrobial agent, particularly against resistant bacterial strains, and underscore the importance of synergistic interactions between compounds in enhancing biological effects.

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Chemical Characterization and Antimicrobial Activity of Green Propolis from the Brazilian Caatinga Biome

Aldana-Mejía,

Ribeiro,

Katragunta

et al. 2024

Plants

View full text Add to dashboard Cite

show abstract

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A Validated RP-HPLC–DAD Method for Analyzing Flavonoids in Caatinga Brazilian Green Propolis from Mimosa tenuiflora Produced by Apis mellifera

Cited by 1 publication

References 15 publications

Chemical Characterization and Antimicrobial Activity of Green Propolis from the Brazilian Caatinga Biome

Chemical Characterization and Antimicrobial Activity of Green Propolis from the Brazilian Caatinga Biome

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