A validated UHPLC-MS/MS method for quantification of total and free tedizolid concentrations in human plasma

Tanaka, Ryota; Kai, Makoto; Shinohara, Shunjiro; Tatsuta, Ryosuke

doi:10.1016/j.jpba.2022.114929

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…5.1.5. The Potential Role of TDM LC-MS/MS methods are available in the literature to monitor tedizolid concentrations in clinical practice [161][162][163]. However, no safety and/or efficacy clinical cutoff for tedizolid trough concentrations has yet been identified, and a TDM of tedizolid is presently considered unnecessary [164].…”

Section: Pk/pd Characteristicsmentioning

confidence: 99%

New Antimicrobials for Gram-Positive Sustained Infections: A Comprehensive Guide for Clinicians

Carcione,

Intra,

Andriani

et al. 2023

Pharmaceuticals

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Antibiotic resistance is a public health problem with increasingly alarming data being reported. Gram-positive bacteria are among the protagonists of severe nosocomial and community infections. The objective of this review is to conduct an extensive examination of emerging treatments for Gram-positive infections including ceftobiprole, ceftaroline, dalbavancin, oritavancin, omadacycline, tedizolid, and delafloxacin. From a methodological standpoint, a comprehensive analysis on clinical trials, molecular structure, mechanism of action, microbiological targeting, clinical use, pharmacokinetic/pharmacodynamic features, and potential for therapeutic drug monitoring will be addressed. Each antibiotic paragraph is divided into specialized microbiological, clinical, and pharmacological sections, including detailed and appropriate tables. A better understanding of the latest promising advances in the field of therapeutic options could lead to the development of a better approach in managing antimicrobial therapy for multidrug-resistant Gram-positive pathogens, which increasingly needs to be better stratified and targeted.

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