Clinical personality assessment is not widely used in industrial/organizational psychology for employment selection. The assessment of personality and mental health problems in employment settings is primarily used in evaluating applicants for law enforcement, fire department, nuclear power plant, and airline pilot positions, in which high emotional stability, successful stress skills, and high responsibility are considered important to the performance of a high-risk job. The clinical personality assessment is characteristically conducted post hire and seen as analogous to the pre-employment medical examination. The most widely used psychological test in this application is the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) which has a substantial research base (more than 600 studies) supporting its use. This article provides interpretive guidelines for the MMPI-2 in personnel screening and suggests an effective strategy (retest method) for dealing with defensive applicants.