A Variable Reference Trajectory for Model-Free Glycemia Regulation

Abstract

The control design of an artificial pancreas, a hot research topic in diabetology, is tackled via the newly introduced model-free control and its corresponding "intelligent" proportional controller, which were already quite successful in many concrete and diverse situations. It results in an insulin injection for type 1 diabetes which displays via constant references a good nocturnal/fasting response, but unfortunately a poor postprandial behavior due to long hyperglycemia. When a variable reference is introduced, that switches between a constant one, when glycemia is more or less normal or moderate, and an exponential decay reference path, when a high glycemia rate indicates a meal intake, the results in silico, which employ real clinical data, become excellent. We obtain a bolus-shaped insulin injection rate during postprandial phases. The hyperglycemic peaks are therefore lowered a lot.

Model-free immune therapy: A control approach to acute inflammation

“…This paper suggests another route, namely the recent model-free setting and the corresponding "intelligent" controllers [20]. 2 It is worthwhile to recall that model-free control has already been successfully applied in quite diverse case-studies (see, e.g., [32], [37], [38], [55] in the field of "life engineering"). The modeling remains nevertheless irreplaceable at this stage for in silico testing, i.e., for computer simulations.…”