A Variant Myelodysplastic Syndrome with Multilineage Pelgeroid Chromatin

Abstract

An unusual myelodysplastic syndrome with similar features in two patients is described. The entity is characterized by a maturation arrest at the myelocyte stage, strikingly clumpy chromatin, and a clinical course marked primarily by difficulties caused by anemia and thrombocytopenia. Electron microscopic description of the characteristic abnormal clumpy chromatin cells is included. While the disorder is unquestionably a myelodysplastic syndrome, it is clearly distinct from chronic myelogenous leukemia, chronic myelomonocytic leukemia, and the spectrum of refractory anemias with excess blasts.

Dysplastic changes in idiopathic thrombocytopenic purpura and the effect of corticosteroids to increase dysplasia and cause hyperdiploid macropolycytes

“…Our study demonstrates that patients with ITP display the aforementioned dysplastic changes in neutrophils (Table I). Therapy with corticosteroids gives rise to a significant increase in neutrophils with bizarre nuclei and nuclei with chromatine clumping which are already encountered in several disorders [1,5,7,[16][17][18][19][20][21][22][23]. The dysplastic features have existed in the eosinophils also.…”

The CD11/CD18 granulocyte adhesion molecules in myelodysplastic syndromes

“…It may 'disappear' with remission, thus suggesting that the abnormal cell line has been eliminated (Dorr & Moloney, 1959;Taylor, 1973;Quie & Cates, 1977;Mazzone et al, 1986Mazzone et al, , 1988Weil & Rose, 1986). It may 'disappear' with remission, thus suggesting that the abnormal cell line has been eliminated (Dorr & Moloney, 1959;Taylor, 1973;Quie & Cates, 1977;Mazzone et al, 1986Mazzone et al, , 1988Weil & Rose, 1986).…”

“…PMNs dysfunction in MDS often develops near to the terminal stage of the disease and may appear in treated as well as in untreated cases. It may 'disappear' with remission, thus suggesting that the abnormal cell line has been eliminated (Dorr & Moloney, 1959;Taylor, 1973;Quie & Cates, 1977;Mazzone et al, 1986Mazzone et al, , 1988Weil & Rose, 1986). The aetiopathogenesis of the acquired granulocytes dysplasia is unknown.…”

“…The aetiopathogenesis of the acquired granulocytes dysplasia is unknown. An intrinsic or extrinsic influence appears to The CD11/CD18 of Granulocytes in MDS 249 result in arrest or dysplasia of nuclear chromatin development (Weil& Rose, 1986). Leder, (1969) has stated that the presence of acquired dysplastic granulocytes in haematological disorders supports the diagnosis of the myelogenous nature of a disease.…”