A Variant of AESOP Syndrome (Adenopathy and Extensive Skin Patch Overlying a Plasmacytoma)

Rongioletti, Franco; Rebora, Alfredo

doi:10.1001/jamadermatol.2013.4763

Cited by 2 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Histological examination of this plaque revealed a similar vascular proliferation without dermal mucin deposition and with pleomorphic, multinucleated histiocytes. While there has been some discussion regarding whether this case was an example of AESOP or MCAH, the plaque interestingly resolved with radiation and chemotherapy as is reported in AESOP …”

Section: Discussionmentioning

confidence: 83%

Adenopathy and extensive skin patch overlying a plasmacytoma with unusual histologic findings in a patient with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes syndrome and Castleman disease

et al. 2019

View full text Add to dashboard Cite

A 56-year-old previously healthy man presented to the dermatology clinic with a 2-year history of an expanding, violaceous, infiltrated plaque on the right flank. Biopsy revealed a diffuse dermal vascular proliferation of bland, capillary-sized vessels admixed with conspicuous fibrohistiocytic cells including scattered multinucleated floret cells. Further workup revealed a monoclonal gammopathy, an osteolytic chest wall plasmacytoma underlying the plaque, and regional lymphadenopathy leading to a diagnosis of adenopathy and extensive skin patch overlying a plasmacytoma (AESOP).Biopsy of an enlarged lymph node revealed Castleman disease. The patient subsequently developed polyneuropathy and peripheral edema, which supported an additional diagnosis of polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes (POEMS) syndrome. Herein, we discuss the unique findings of our patient, the potential pathogenesis of AESOP, and the link between these three rare paraneoplastic entities along with review of the literature. K E Y W O R D S adenopathy and extensive skin patch overlying a plasmacytoma, AESOP, Castleman disease, POEMS, polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes

show abstract

Section: Discussionmentioning

confidence: 83%

Adenopathy and extensive skin patch overlying a plasmacytoma with unusual histologic findings in a patient with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes syndrome and Castleman disease

et al. 2019

View full text Add to dashboard Cite

show abstract

“…5 However, diagnosing the cutaneous manifestations remains challenging because of the nonspecific clinical presentation and the resemblance of histopathologic features of other skin lesions observed in skin biopsies. 7,8 We describe the presentation of AESOP in a 48-yearold woman with a history of MGUS who presented with a progressively enlarging red plaque on her chest and required multiple skin biopsies more than a period of 2 years to reach a definitive diagnosis (Figs. 1A, 2A).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Concomitant AESOP and POEMS Syndrome in the Context of Osseous and Cutaneous Plasmacytomas: Answer

Shaker,

Sangueza

2023

The American Journal of Dermatopathology

View full text Add to dashboard Cite

A Variant of AESOP Syndrome (Adenopathy and Extensive Skin Patch Overlying a Plasmacytoma)

Cited by 2 publications

References 6 publications

Adenopathy and extensive skin patch overlying a plasmacytoma with unusual histologic findings in a patient with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes syndrome and Castleman disease

Adenopathy and extensive skin patch overlying a plasmacytoma with unusual histologic findings in a patient with polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin changes syndrome and Castleman disease

Concomitant AESOP and POEMS Syndrome in the Context of Osseous and Cutaneous Plasmacytomas: Answer

Contact Info

Product

Resources

About