A Variant of <i>IL1B</i> Is Associated with the Risk and Blood Lipid Levels of Myocardial Infarction in Eastern Chinese Individuals

Pan, Quanhua; Ding, Hui; Hu, Chuangxian

doi:10.1080/08820139.2021.1914081

Cited by 8 publications

(9 citation statements)

References 42 publications

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“…These genes were subjected to PPI analysis, resulting in the identification of 10 hub genes. The hub genes identified were IL1B, ZAP70, LCK, FASLG, CD4, LRP1, CDH2, MERTK, APOE and VTN and IL1B was the crucial genes among them.IL‐1B is a key pro‐inflammatory cytokine that is associated with the development of atherosclerosis and MI 23 . IL1B gene polymorphisms affect the risk of MI and ischemic stroke in young adults by modulating the expression of NF‐κB, iNOS, MMP‐2, and Bax 24 .…”

Section: Discussionmentioning

confidence: 99%

Identification of important genes related to anoikis in acute myocardial infarction

Song,

Yakufujiang,

Zhou

et al. 2024

J Cellular Molecular Medi

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Acute myocardial infarction (AMI) increasingly precipitates severe heart failure, with diagnoses now extending to progressively younger demographics. The focus of this study was to pinpoint critical genes linked to both AMI and anoikis, thereby unveiling potential novel biomarkers for AMI detection and intervention. Differential analysis was performed to identify significant differences in expression, and gene functionality was explored. Weighted gene coexpression network analysis (WGCNA) was used to construct gene coexpression networks. Immunoinfiltration analysis quantified immune cell abundance. Protein–protein interaction (PPI) analysis identified the proteins that interact with theanoikis. MCODE identified key functional modules. Drug enrichment analysis identified relevant compounds explored in the DsigDB. Through WGCNA, 13 key genes associated with anoikis and differentially expressed genes were identified. GO and KEGG pathway enrichment revealed the regulation of apoptotic signalling pathways and negative regulation of anoikis. PPI network analysis was also conducted, and 10 hub genes, such as IL1B, ZAP70, LCK, FASLG, CD4, LRP1, CDH2, MERTK, APOE and VTN were identified. IL1B were correlated with macrophages, mast cells, neutrophils and Tcells in MI, and the most common predicted medications were roxithromycin, NSC267099 and alsterpaullone. This study identified key genes associated with AMI and anoikis, highlighting their role in immune infiltration, diagnosis and medication prediction. These findings provide valuable insights into potential biomarkers and therapeutic targets for AMI.

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Section: Discussionmentioning

confidence: 99%

Identification of important genes related to anoikis in acute myocardial infarction

Song,

Yakufujiang,

Zhou

et al. 2024

J Cellular Molecular Medi

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“…Moreover, the IL-1β gene, which releases IL-1β as a proinflammatory agent, is associated with cardiovascular diseases, including coronary artery disease, stent restenosis after percutaneous coronary interventions, carotid artery disease, lone atrial fibrillation, and CSFP [42][43][44][45]. In addition, the 315C/T nucleotide transition of the IL-1β gene probably modulates IL-1β protein synthesis and is associated with such cardiovascular diseases as CSFP, coronary artery disease, and myocardial infarction [25,[46][47][48][49]. Previous studies have also indicated the role of genetic predisposing factors in the occurrence of CSFP [22][23][24]50].…”

Section: Discussionmentioning

confidence: 99%

“…From 2016 through 2017, a total of 180 patients with CSFP (49 women [27.2%]) at a median age of 55 (48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59)(60)(61)(62) years were enrolled in the CSFP group. From 2016 through 2018, a total of 87 individuals with normal coronary arteries (56 women [64.4%]) at a median age of 47 (41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58) years were enrolled in the control group. The baseline and clinical characteristics of both groups are summarized in Table 1.…”

Section: Clinical Characteristics Of the Study Populationmentioning

confidence: 99%

“…Additionally, the levels of plasma creatinine, triglyceride, and hemoglobin were higher in the patients with CSFP than in the control group. The median value (Q1-Q3) TFC for the left anterior descending coronary artery, the left circumflex artery, and the right coronary artery was 36 (29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43), 40 (31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50), and 31.5 (24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)…”

Section: Clinical Characteristics Of the Study Populationmentioning

confidence: 99%

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Endothelial nitric oxide synthase Asp298Glu (894G/T) gene polymorphism as a possible risk factor for the coronary slow flow phenomenon among Iranians

Karimi

Sehati

Sarreshtedari

et al. 2022

BMC Cardiovasc Disord

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Background Mounting evidence indicates an association between endothelial dysfunction and the coronary slow flow phenomenon (CSFP). In the present study, we aimed to evaluate the possible role of endothelial nitric oxide synthase (eNOS) 894G/T and interleukin-1β (IL-1β) 315C/T polymorphisms as possible risk factors for CSFP. Methods This prospective study enrolled patients with CSFP and individuals with normal coronary arteries. Genotypes were assessed using regular polymerase chain reaction and direct Sanger-sequencing techniques. Results The study population consisted of 267 individuals: 180 patients with CSFP (49 women [27.2%]) at a median age of 55 (48–62) years and 87 controls with normal coronary arteries (56 women [64.4%]) at a median age of 47 (41–58) years. The allelic distribution of eNOS 894G/T was significantly associated with CSFP (odds ratio [OR], 1.58; 95% confidence interval (CI), 1.04–2.42; P = 0.03). This polymorphism increased the risk of CSFP under the dominant model (OR 1.73; 95% CI I.02–2.95; P = 0.04). However, the allelic frequencies (1.05; 95% CI 0.68–1.59; P = 0.83) and genotypic frequencies (0.88; 95% CI 0.52–1.49; P = 0.63) of the IL-1β 315C/T polymorphism were not associated with the incidence of CSFP in the Iranian population. Conclusions The CSFP and control groups were statistically different regarding the eNOS 894G/T polymorphism. Our findings also demonstrated that the IL-1β 315C/T polymorphism was not a risk factor for CSFP.

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“…Similarly, carriers of GA genotype of rs726344 have displayed significantly increased levels of CKMB, total cholesterol, LDLc, HDLc, Troponin I, and triglycerides when compared to individuals with other genotypes, which further increases the risk of MI (Badr EA., et al, 2020). Furthermore, rs1143634 C/T in IL1B is also associated with blood lipid levels, including low-density lipoprotein (LDL) and total cholesterol (TC), in the Eastern Chinese Han population, potentially influencing MI risk (Pan Q., et al, 2021). Conversely, in a population from Western Siberia (Russia), the presence of the G allele of rs708272 has been associated with lower levels of high-density lipoprotein cholesterol and a higher index of atherogenicity, implicating this SNP in the development of MI (Semaev S., et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

In-silicoanalysis of Myocardial Infarction-related missense SNPs to identify novel biomarkers to predict susceptibility

Tarlochan,

Rasool

2023

Preprint

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Myocardial Infarction (MI), commonly known as a heart attack, stands as a formidable global health challenge, responsible for a substantial burden of morbidity and mortality. This study embarked on a comprehensive exploration of the genetic underpinnings of MI, recognizing the pivotal role of genetic factors in determining an individual’s susceptibility to this life-threatening condition. The objective of our research was to investigate missense single nucleotide polymorphisms (SNP) associated with MI to determine whether the changes in amino acid sequences have potential implications for the risk of MI. Employing a multifaceted approach, we leveraged an array of computational tools and databases to scrutinize specific missense SNP and meticulously analyzed their potential effects on protein structure stability and function. Our analysis has confirmed a total of 4 missense SNP in ALDH2, APOE, IGFBP1, and PCSK1 genes to be damaging to protein structure and hence, the function. An extensive literature review was then performed to determine the functional roles of these genes in the regulation of the cardiac system-related pathways. Our analysis confirmed that all 2 of these genes are directly involved in pathways related to the cardiac system, while the other 2 genes play other roles. We have further analyzed their interactions and underlying biological processes to determine their potential role in the incidence of MI. These findings collectively offer a profound understanding of the intricate genetic landscape underlying MI. They not only enhance our comprehension of the multifaceted genetic factors influencing MI susceptibility but also set the stage for future experimental investigations. Importantly, these insights hold the potential to guide future research and the development of therapeutic strategies, to improve the prevention and management of this critical cardiovascular condition.

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A Variant of IL1B Is Associated with the Risk and Blood Lipid Levels of Myocardial Infarction in Eastern Chinese Individuals

Cited by 8 publications

References 42 publications

Identification of important genes related to anoikis in acute myocardial infarction

Identification of important genes related to anoikis in acute myocardial infarction

Endothelial nitric oxide synthase Asp298Glu (894G/T) gene polymorphism as a possible risk factor for the coronary slow flow phenomenon among Iranians

In-silicoanalysis of Myocardial Infarction-related missense SNPs to identify novel biomarkers to predict susceptibility

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