A variant rs6214 within IGF-1 confers risk for ulcerative colitis in Chinese Han populations

Wang, Huiping; Wang, Jin; Geng, Chunsong; Gu, Rentao; Zhu, Zhansheng

doi:10.1007/s10142-022-00921-0

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…The pathology of the disease may start with events that impair the mucosal barrier, cause intestinal microbiota imbalance, and encourage an abnormal intestinal immune response. In addition, genetic predisposition is relevant for the development of the disease [ 99 , 100 ].…”

Section: Physiopathology Of Ucmentioning

confidence: 99%

Effects of Medicinal Plants and Phytochemicals in Nrf2 Pathways during Inflammatory Bowel Diseases and Related Colorectal Cancer: A Comprehensive Review

et al. 2023

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Inflammatory bowel diseases (IBDs) are related to nuclear factor erythroid 2-related factor 2 (Nrf2) dysregulation. In vitro and in vivo studies using phytocompounds as modulators of the Nrf2 signaling in IBD have already been published. However, no existing review emphasizes the whole scenario for the potential of plants and phytocompounds as regulators of Nrf2 in IBD models and colitis-associated colorectal carcinogenesis. For these reasons, this study aimed to build a review that could fill this void. The PubMed, EMBASE, COCHRANE, and Google Scholar databases were searched. The literature review showed that medicinal plants and phytochemicals regulated the Nrf2 on IBD and IBD-associated colorectal cancer by amplifying the expression of the Nrf2-mediated phase II detoxifying enzymes and diminishing NF-κB-related inflammation. These effects improve the bowel environment, mucosal barrier, colon, and crypt disruption, reduce ulceration and microbial translocation, and consequently, reduce the disease activity index (DAI). Moreover, the modulation of Nrf2 can regulate various genes involved in cellular redox, protein degradation, DNA repair, xenobiotic metabolism, and apoptosis, contributing to the prevention of colorectal cancer.

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Section: Physiopathology Of Ucmentioning

confidence: 99%

Effects of Medicinal Plants and Phytochemicals in Nrf2 Pathways during Inflammatory Bowel Diseases and Related Colorectal Cancer: A Comprehensive Review

et al. 2023

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“…19 As ongoing work concentrates on the development of novel delivery methods and the reduction of potential side effects, including off-target impacts, the utilization of CRISPR/Cas9 in cancer research and treatment is projected to expand. 20 The study aims to investigate the integration of nanoparticles with CRISPR/Cas9 for improved cancer diagnosis and therapy, capitalising on the remarkable advancements in CRISPR/Cas9 technology and its prospective applications in the field of cancer diagnosis and therapy.…”

Section: Introductionmentioning

confidence: 99%