2001
DOI: 10.1002/jlcr.25804401371
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A versatile, commercially available automated synthesizer for the development and production of pet radiotracers

Abstract: The automation of routinely produced radiotracers is an important process for any PET center. Automation allows frequent, highly reproducible syntheses with large amounts of radioactivity while minimizing exposure to the radiochemist in comparison with manual radiotracer synthesis. We found the Gilson SK233 Work Station, coupled with Gilson's 735 Sampler Software and a Gilson SPE (solid phase extraction) module, to be a versatile, user-friendly, and cost-effective solution to our need for automation in the dev… Show more

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Cited by 11 publications
(9 citation statements)
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“…The microwave apparatus Model 521A was obtained from Resonance Instruments (Skokie, IL). Radiochemical procedures were carried out remotely in a lead hot cell using a modified Gilson 233XL liquid handler (Hostetler et al, 2001). Radiotracers were purified by reverse-phase HPLC using a Waters Model 600E controller (Milford, MA).…”
Section: Methodsmentioning
confidence: 99%
“…The microwave apparatus Model 521A was obtained from Resonance Instruments (Skokie, IL). Radiochemical procedures were carried out remotely in a lead hot cell using a modified Gilson 233XL liquid handler (Hostetler et al, 2001). Radiotracers were purified by reverse-phase HPLC using a Waters Model 600E controller (Milford, MA).…”
Section: Methodsmentioning
confidence: 99%
“…All other reagents and solvents were obtained from either Fisher Scientific or Aldrich. Radiochemical procedures were carried out remotely in a lead hot cell using a modified 233XL liquid handler (Gilson Inc.) (15). PET tracer identity, radiochemical purity, and specific activity were determined by evaluation on a Agilent 1100 LC system (Agilent Technologies) equipped with a FlowCount photodiode radiodetector (Bioscan Inc.).…”
Section: Generalmentioning
confidence: 99%
“…4 However, examples of using microwave reactors for azeotropic drying of the [ 18 F]fluoride ions are rare, and automated radiopharmaceutical production devices that include a microwave reactor are virtually non-existent. 5 We developed a fully automated radiofluorination module by integrating the Resonance Instrument 521 microwave reactor 6 with a Synthia radiosynthesis device. 7 The microwave reactor provides efficient heating and Synthia provides an automation platform.…”
Section: F]fluoride Ion Is Produced As An Aqueous Solution In a [mentioning
confidence: 99%