A versatile functional interaction between electrically silent KV subunits and KV7 potassium channels
Vijay Renigunta,
Nermina Xhaferri,
Imran Gousebasha Shaikh
et al.
Abstract:Voltage-gated K+ (KV) channels govern K+ ion flux across cell membranes in response to changes in membrane potential. They are formed by the assembly of four subunits, typically from the same family. Electrically silent KV channels (KVS), however, are unable to conduct currents on their own. It has been assumed that these KVS must obligatorily assemble with subunits from the KV2 family into heterotetrameric channels, thereby giving rise to currents distinct from those of homomeric KV2 channels. Herein, we show… Show more
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