A versatile photoelectrochemical biosensor based on in-situ grown 2D COFs film for sensitive detection of Hg2+ and aflatoxin B1

Niu, Xiankang; Yang, Yudie; Duan, Binqiu; Li, Chunlong; Zhang, Yuexing; Zhang, Xiaomei

doi:10.1016/j.cej.2024.152628

Chemical Engineering Journal

2024

DOI: 10.1016/j.cej.2024.152628

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A versatile photoelectrochemical biosensor based on in-situ grown 2D COFs film for sensitive detection of Hg2+ and aflatoxin B1

Xiankang Niu,

Yudie Yang,

Binqiu Duan

et al.

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Cited by 2 publications

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Construction of pyrrolo[3,2-b]pyrrolyl-linked covalent organic polymers to promote continuous overall H2O2 production

Li,

He,

Wang

et al. 2024

Nano Energy

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Construction of pyrrolo[3,2-b]pyrrolyl-linked covalent organic polymers to promote continuous overall H2O2 production

Li,

He,

Wang

et al. 2024

Nano Energy

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Efficient Multidriven Strand Displacement Reaction for Biosensing

Zhang,

Zhou,

Deng

et al. 2024

Anal. Chem.

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A key challenge for achieving high-efficient DNA strand displacement reaction (SDR) with existing technologies is the inferior kinetic performance due to the alternately cumbersome conjunction and dissociation of dsDNA. In this work, a novel multidriven SDR collaborated by toehold initiator, strand towing, and click chemistry is engineered. The invasion strand (O) endows the hybridization with a basal strand (M) in dsDNA for releasing a displacement strand (P), which can be significantly boosted by the towing of a helper strand and impetus from the click reaction. Accordingly, the hybridization rate and dissociation extent of P can be largely improved and showed a desiring displacement rate close to 6-fold compared with the traditional method, providing a newly high-efficient SDR strategy for potential application in biosensing, clinical diagnostics, and DNA nanotechnology. In view of this, a practical biosensing platform by combining the multidriven SDR (MSDR) with waste-free DNA multi-cycle amplification is constructed for the rapid and ultrasensitive electrochemical detection of cancer-related miRNA-21. The substantial output DNA as an invasion strand (O) from target-triggered waste-free DNA multicycle can high-efficiently release a signal probe (Fc)-labeled displacement strand (P) on an electrode by using the proposed MSDR, obtaining a low detection limit below 106.8 aM.

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A versatile photoelectrochemical biosensor based on in-situ grown 2D COFs film for sensitive detection of Hg2+ and aflatoxin B1

Cited by 2 publications

References 40 publications

Construction of pyrrolo[3,2-b]pyrrolyl-linked covalent organic polymers to promote continuous overall H2O2 production

Construction of pyrrolo[3,2-b]pyrrolyl-linked covalent organic polymers to promote continuous overall H2O2 production

Efficient Multidriven Strand Displacement Reaction for Biosensing

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