A Versatile Six-Component Molecular Capsule Based on Benign Synthons − Selective Confinement of a Heterogeneous Molecular Aggregate

Cave, Gareth W. V.; Hardie, Michaele J.; Roberts, Brett A.; Raston, Colin L.

doi:10.1002/1099-0690(200109)2001:17<3227::aid-ejoc3227>3.0.co;2-v

Cited by 80 publications

(36 citation statements)

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“…[8][9][10] Although the confined guest matrix within these molecular containers has been regarded as a new phase of matter, [11] a detailed understanding of the interplay and relative orientations of the constituent guest molecules has, until now, been restricted to a few instances of limited complexity. [12,13] We previously described the self-assembly of the pyrogallol [4]arene building block into a globular hexamer, which is stable even in aqueous media. [8,14] To date, only capsules composed of C-isobutylpyrogallol [4]arene [8,14,15] and C-propylpyrogallol [4]arene [16] have been structurally authenticated by X-ray single-crystal structure analysis.…”

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confidence: 99%

Inner Core Structure Responds to Communication between Nanocapsule Walls

et al. 2004

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confidence: 99%

Inner Core Structure Responds to Communication between Nanocapsule Walls

et al. 2004

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“…Pyridine functionalities have been widely studied [1,2] and widely used [3][4][5][6] but still generate much interest due to their wide range of application in medicinal chemistry [7][8][9][10][11]. The naturally occurring B6-vitamins pyridoxine, pyrodoxal, pyridoxamine and codecarbaxylase contain a pyridine nucleus [12].…”

Section: Inroductionmentioning

confidence: 99%

Synthesis and Antimicrobial Screening 6-Aryl-2-(Amino/Methoxy)-4-[(4′-Difluoro Methoxy) (3′-Hydroxy) Phenyl] Nicotinonitrile

Bhadani¹,

Patel²,

Purohit³

et al. 2015

ILCPA

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A series of an easy and efficient route for the synthesis of some new 2-amino-3-cyanopyridine (4a-4i) and 2-methoxy-3-cyanopyridine (5a-5i) derivatives were synthesized through the reaction of various chalcone (3a-3i) with malononitrile in presence of ammonium acetate and sodium methoxide, respectively. The constitutions of the all synthesized compounds have been established by the IR, 1H-NMR, Mass spectral data and Elemental analysis. Furthermore, all the synthesized products were screened for their antimicrobial activity. INRODUCTIONPyridine functionalities have been widely studied [1,2] and widely used [3-6] but still generate much interest due to their wide range of application in medicinal chemistry [7][8][9][10][11]. The naturally occurring B6-vitamins pyridoxine, pyrodoxal, pyridoxamine and codecarbaxylase contain a pyridine nucleus [12]. Pyridine derivatives have been used as herbicides [13] [23]. Most derivatives are prepared by manipulation of pyridine and its simple homologues in a manner similar to chemistry of the benzenoid chemistry. However the simple pyridine compounds are prepared by the cyclization of aliphatic raw materials. The pyridine nucleus is found in a large number of commonly used drugs which have diverse pharmacological activities. Interests in the synthesis of multicyclic pyridine containing compounds have increased in recent years because of their biological and pharmacological activities.The structure of synthesized compounds were assigned based on Elemental analysis, IR 1H-NMR and Mass spectral data. The antimicrobial activity was assayed by using the MIC (Minimum Inhibitory Concentration) method. All the compounds were screened in vitro for their antimicrobial activities against Gram +ve bacteria, Gram -ve bacteria and fungi. The biological activities of the synthesized compounds were compared with known standard drugs. RESULTS AND DISCUSSIONThe synthetic route adopted to obtain the 3-cyanopyridine derivatives 4a-4i and 5a-5i is shown in Scheme 1. 2-Amino-3-cyanopyridine derivatives 4a-4i were prepared from Chalcones 3a-3i by refluxing with malononitrile and ammonium acetate in Ethanol. The isolated product was crystallized with diethyl ether to get 2-amino-3-cyanopyridine derivatives in 58-83% yield. The 2-methoy-3-cyanopyridine derivatives 5a-5i were prepared from Chalcones 3a-3i by refluxing with

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“…Essentially, these compounds serve as high-potency agonists for the human adenosine receptors and act as potential therapeutic agents for the treatment of Creutzfeldt-Jacob disease, Parkinson's disease, hypoxia, asthma, cancer, kidney disease and prion disease [3][4][5]. Due to their п-stacking ability, some pyridines are used in supramolecular chemistry [6][7][8]. Previously, 2,4,6-triarylpyridines have been prepared by the condensation of 1,5-diketones with formamide-formic acid [9], reaction of (aroylmethylene) isoquinolinium ylide with α, β-unsaturated ketones [10,11], and reaction of N-phenacylpyridinium salts with α, β-unsaturated ketones in the presence of ammonium acetate [12].…”

Section: Introductionmentioning

confidence: 99%

Montmorillonite K10 Clay Catalyzed One Pot Synthesis of 2,4,6-Tri Substituted Pyridine under Solvent Free Condition

Kannan¹,

Sreekumar²

2013

MRC

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Montmorillonite K10 catalyzed synthesis of 2,4,6 triaryl pyridine under solvent free condition is described. Montmorillonite effectively catalyzed the reaction in good to excellent yields. Using this solid catalyst, the reactions could be carried out in a short period of time with very good yield of triaryl pyridines, up to 97% under solvent free condition. This catalyst could be recycled very easily, which makes this methodology environmentally benign. The catalyst is active over three cycles.

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A Versatile Six-Component Molecular Capsule Based on Benign Synthons − Selective Confinement of a Heterogeneous Molecular Aggregate

Cited by 80 publications

References 17 publications

Inner Core Structure Responds to Communication between Nanocapsule Walls

Inner Core Structure Responds to Communication between Nanocapsule Walls

Synthesis and Antimicrobial Screening 6-Aryl-2-(Amino/Methoxy)-4-[(4′-Difluoro Methoxy) (3′-Hydroxy) Phenyl] Nicotinonitrile

Montmorillonite K10 Clay Catalyzed One Pot Synthesis of 2,4,6-Tri Substituted Pyridine under Solvent Free Condition

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