A versatile synthetic strategy for macromolecular cages: intramolecular consecutive cyclization of star-shaped polymers

Mato, Yoshinobu; Honda, Kohei; Tajima, Kenji; Yamamoto, Takuya; Isono, Takuya; Satoh, Toshifumi

doi:10.1039/c8sc04006k

Cited by 35 publications

(42 citation statements)

References 41 publications

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“…Inspired by the self‐folding of biomacromolecules, such as proteins and nucleic acids, intramolecular cross‐linking reactions of random‐coiled synthetic polymers into defined structures, e.g., cyclic polymers, [1–5] cage‐shaped polymers, [6–10] and single‐chain nanoparticles (SCNPs), [11–18] have attracted significant interest. Among these unique single‐chain technologies, the intramolecular cross‐linking of linear polymers bearing cross‐linkable functionalities along the main chain to generate a three‐dimensional SCNP had been widely studied, aiming at creating functional nanomaterials, such as catalysts, [19–23] nanocarriers, [24–27] and stimuli‐responsive sensors [28–31] …”

Section: Introductionmentioning

confidence: 99%

One‐Shot Intrablock Cross‐Linking of Linear Diblock Copolymer to Realize Janus‐Shaped Single‐Chain Nanoparticles

et al. 2021

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Developing an efficient and versatile process to transform as ingle linear polymer chain into as hape-defined nanoobject is am ajor challenge in the fields of chemistry and nanotechnology to replicate sophisticated biological functions of proteins and nucleic acids in asynthetic polymer system. In this study,w ep erformed one-shot intrablockc ross-linking of linear blockc opolymers (BCPs) to realizes ingle-chain nanoparticles (SCNPs) with two chemically compartmentalized domains (Janus-shaped SCNPs). Detailed structural characterizations of the Janus-shaped SCNP composed of polystyreneblock-poly(glycolic acid) revealed its compactly folded conformation and compartmentalized blockl ocalization, similar to the self-folded tertiary structures of natural proteins. Versatility of the one-shot intrablockc ross-linking was demonstrated using several different BCP precursors.I na ddition, the Janus-shaped SCNP produce miniscule microphase-separated structures.

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Section: Introductionmentioning

confidence: 99%

One‐Shot Intrablock Cross‐Linking of Linear Diblock Copolymer to Realize Janus‐Shaped Single‐Chain Nanoparticles

et al. 2021

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“…This analog of aliphatic polyesters can be reacted with the chain-end hydroxyl group(s) to perform further functionalization, modifications, or chain extensions. Thus, the limited numbers of functionalizable end(s) thus can be anticipated [ 32 , 33 , 34 ]. However, rendering a variety of functional groups on aliphatic polyester backbones remains challenging since ROP cannot usually tolerate high-polar groups [ 35 , 36 , 37 , 38 , 39 ].…”

Section: Synthesis Of Functional Aliphatic Polyesters and Polycarbmentioning

confidence: 99%

Progress in the Preparation of Functional and (Bio)Degradable Polymers via Living Polymerizations

Lin

Wang

Chang

et al. 2020

IJMS

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This review presents the latest developments in (bio)degradable approaches and functional aliphatic polyesters and polycarbonates prepared by typical ring-opening polymerization (ROP) of lactones and trimethylene carbonates. It also considers several recent innovative synthetic methods including radical ring-opening polymerization (RROP), atom transfer radical polyaddition (ATRPA), and simultaneous chain- and step-growth radical polymerization (SCSRP) that produce aliphatic polyesters. With regard to (bio)degradable approaches, we have summarized several representative cleavable linkages that make it possible to obtain cleavable polymers. In the section on functional aliphatic polyesters, we explore the syntheses of specific functional lactones, which can be performed by ring-opening copolymerization of typical lactone/lactide monomers. Last but not the least, in the recent innovative methods section, three interesting synthetic methodologies, RROP, ATRPA, and SCSRP are discussed in detail with regard to their reaction mechanisms and polymer functionalities.

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“…Inspired by the self-folding of biomacromolecules,such as proteins and nucleic acids,i ntramolecular cross-linking reactions of random-coiled synthetic polymers into defined structures,e.g., cyclic polymers, [1][2][3][4][5] cage-shaped polymers, [6][7][8][9][10] and single-chain nanoparticles (SCNPs), [11][12][13][14][15][16][17][18] have attracted significant interest. Among these unique single-chain technologies,t he intramolecular cross-linking of linear polymers bearing cross-linkable functionalities along the main chain to generate athree-dimensional SCNP had been widely studied, aiming at creating functional nanomaterials,s uch as catalysts, [19][20][21][22][23] nanocarriers, [24][25][26][27] and stimuli-responsive sensors.…”

Section: Introductionmentioning

confidence: 99%

One‐Shot Intrablock Cross‐Linking of Linear Diblock Copolymer to Realize Janus‐Shaped Single‐Chain Nanoparticles

et al. 2021

Self Cite

View full text Add to dashboard Cite

Developing an efficient and versatile process to transform a single linear polymer chain into a shape‐defined nanoobject is a major challenge in the fields of chemistry and nanotechnology to replicate sophisticated biological functions of proteins and nucleic acids in a synthetic polymer system. In this study, we performed one‐shot intrablock cross‐linking of linear block copolymers (BCPs) to realize single‐chain nanoparticles (SCNPs) with two chemically compartmentalized domains (Janus‐shaped SCNPs). Detailed structural characterizations of the Janus‐shaped SCNP composed of polystyrene‐block‐poly(glycolic acid) revealed its compactly folded conformation and compartmentalized block localization, similar to the self‐folded tertiary structures of natural proteins. Versatility of the one‐shot intrablock cross‐linking was demonstrated using several different BCP precursors. In addition, the Janus‐shaped SCNP produce miniscule microphase‐separated structures.

show abstract

A versatile synthetic strategy for macromolecular cages: intramolecular consecutive cyclization of star-shaped polymers

Abstract: Intramolecular consecutive cyclization was established as a versatile and robust strategy to synthesize macromolecular cages.

Cited by 35 publications

References 41 publications

One‐Shot Intrablock Cross‐Linking of Linear Diblock Copolymer to Realize Janus‐Shaped Single‐Chain Nanoparticles

One‐Shot Intrablock Cross‐Linking of Linear Diblock Copolymer to Realize Janus‐Shaped Single‐Chain Nanoparticles

Progress in the Preparation of Functional and (Bio)Degradable Polymers via Living Polymerizations

One‐Shot Intrablock Cross‐Linking of Linear Diblock Copolymer to Realize Janus‐Shaped Single‐Chain Nanoparticles

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