A versatile UCST-type composite microsphere for image-guided chemoembolization and photothermal therapy against liver cancer

Huang, Dan; Dai, Haitao; Tang, Keyu; Chen, Bin; Zhu, Huilian; Chen, Dubo; Li, Nan; Wang, Yingzhao; Liu, Chuwei; Huang, Yonghui; Yang, Jing; Zhang, Chao; Lin, Run; He, Weiling

doi:10.1039/d0nr04592f

Cited by 22 publications

(20 citation statements)

References 34 publications

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“…The main organs have been dissected and fastened to the histopathological analysis using 10% of formalin embedded in paraffin, cut and stained by Hematoxylin and Eosin (H&E) for standard technology. Pictures were obtained with an optical microscope after staining (Sherwani et al., 2015 ; Guo et al., 2019 ; Park et al., 2019 ; Huang et al., 2020 ).…”

Section: Methodsmentioning

confidence: 99%

RETRACTED ARTICLE: A convergent synthetic platform for dual anticancer drugs functionalized by reduced graphene nanocomposite delivery for hepatocellular cancer

Zhang

Han

et al. 2021

Drug Delivery

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Hepatocellular carcinoma (HCC) is widespread cancer with a high degree of morbidity and mortality in individuals worldwide and a serious concern for its resistance to present chemotherapy drugs. In this investigation, the combination of cisplatin (CPT) and metformin (MET) to kill the HepG2 and caco-2 cells was developed into a new pH-responding magnetic nanocomposite based on reduced graphene oxide. Polyhydroxyethyl methacrylic (PHEA) was then linked employing grafting from approach to the reduced graphene oxide by ATRP polymerization (Fe 3 O 4 @rGO-G-PSEA). FT-IR, SEM, XRD, DLS, and TGA analyses evaluated physicochemical characteristics of the nanocomposite. In addition, the cellular uptake property of the nanocomposites was examined by the HepG2 cells. The outcomes of cell viability results indicate that the nanoparticles loaded with MET&CPT showed the lowest concentration rate of HepG2 and Caco-2 cells compared to the drug-loaded single nanocomposite groups and free drugs. The histological analysis has demonstrated relatively safe and does not produce different stress such as swelling and inflammation of the mice organs. Our results show the enhancement in cytotoxicity in HepG2 and Cocoa-2 cells by MET and CPT graphene oxide-based nanocomposite by promoting apoptotic response. Moreover, Fe 3 O 4 @rGO-G-PSEA showed potent in vivo antitumor efficacy but showed no adverse toxicity to normal tissues. Together, this study can provide insight into how surface embellishment may tune these nanocomposites' tumor specificity and provide the basis for developing anticancer efficacy.

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Section: Methodsmentioning

confidence: 99%

RETRACTED ARTICLE: A convergent synthetic platform for dual anticancer drugs functionalized by reduced graphene nanocomposite delivery for hepatocellular cancer

Zhang

Han

et al. 2021

Drug Delivery

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“…It is worth noting that the hyperthermia effect yielded by PNIPAM@GO microspheres in aqueous under NIR irradiation could reach to the required temperature for eliminating tumor cells. 37 To explore the synergistic anti-tumor activity, we encapsulated DOX and 5-FU into PNIPAM core and GO shell respectively, to obtain the predesigned dual-drug loaded PNIPAM@GO microspheres. As above mentioned, the core-shell microspheres displayed excellent photothermal conversion performance under NIR irradiation, thus the thermosensitive PNIPAM cores would shrink in volume upon heating (>32 C) when exposure to NIR, thereby squeezing the loaded DOX out of PNIPAM cores at Stage 1.…”

Section: Resultsmentioning

confidence: 99%

“…To achieve the preset therapeutic temperatures such as room temperature (25°C), body temperature (37°C) and higher temperature (49.9°C), the laser current should be adjusted to meet the heating requirement of PNIPAM@GO microspheres in aqueous, as shown in Figure 4d. It is worth noting that the hyperthermia effect yielded by PNIPAM@GO microspheres in aqueous under NIR irradiation could reach to the required temperature for eliminating tumor cells 37 …”

Section: Resultsmentioning

confidence: 99%

Fabrication of novel PNIPAM@GO microspheres loaded with dual drugs featuring on‐demand drug release capability

Jiang

Wang

et al. 2022

J of Applied Polymer Sci

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In this research, we successfully prepared a new kind of core‐shell microspheres (PNIPAM@GO) composed of hydrophilic poly (N‐isopropyl acrylamide) (PNIPAM) nanoparticles as the core and amphiphilic graphene oxide (GO) nanosheets as the shell through hydrogen bonding and self‐assembly in organic solvent. The temperature‐sensitive behavior of the PNIPAM core made its average size decrease from 888.3 nm to 630.3 nm with temperature increasing from 25°C to 50°C. And the GO shell could give PNIPAM@GO microspheres remarkable photothermal effects in water under NIR laser irradiation (808 nm) for 20 min. Further, doxorubicin (DOX) and 5‐fluorouracil (5‐FU) were loaded into the core and the shell with loading efficiency of 81% and 11%, respectively. By turning on/off NIR irradiation, the PNIPAM@GO microspheres could respond to the heat generated from GO shell by volume shrinkage, thus on‐demand controlling the drug release. The in vitro biological assessment verified that the samples prepared here were biocompatible. The developed platform shows a potential application in chemo‐photothermal therapy of cancers in the future.

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“…The same group later demonstrated that such effects could be intensified by pretreatment with an injection of a vascular disruptor called combretastatin A4-phosphate [63]. Huang et al demonstrated that the combination of therapies with DOX-loaded microspheres containing PDA-functionalized SPIONs improved drug release when a certain temperature threshold was surpassed [64]. Strikingly, PTT/TACE therapy was shown to overcome chemoresistance in HCC cells in vitro by using regular HepG2 cells and chemo-resistant HepG2/ADR cells.…”

Section: Hepatocellular Carcinoma Hepatocellular Carcinoma: Mfhmentioning

confidence: 99%

Iron Oxide Nanoparticle-Based Hyperthermia as a Treatment Option in Various Gastrointestinal Malignancies

et al. 2021

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Iron oxide nanoparticle-based hyperthermia is an emerging field in cancer treatment. The hyperthermia is primarily achieved by two differing methods: magnetic fluid hyperthermia and photothermal therapy. In magnetic fluid hyperthermia, the iron oxide nanoparticles are heated by an alternating magnetic field through Brownian and Néel relaxation. In photothermal therapy, the hyperthermia is mainly generated by absorption of light, thereby converting electromagnetic waves into thermal energy. By use of iron oxide nanoparticles, this effect can be enhanced. Both methods are promising tools in cancer treatment and are, therefore, also explored for gastrointestinal malignancies. Here, we provide an extensive literature research on both therapy options for the most common gastrointestinal malignancies (esophageal, gastric and colorectal cancer, colorectal liver metastases, hepatocellular carcinoma, cholangiocellular carcinoma and pancreatic cancer). As many of these rank in the top ten of cancer-related deaths, novel treatment strategies are urgently needed. This review describes the efforts undertaken in vitro and in vivo.

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A versatile UCST-type composite microsphere for image-guided chemoembolization and photothermal therapy against liver cancer

Abstract: Development of novel chemoembolization agents to improve the treatment efficacy of transarterial chemoembolization (TACE) against liver cancer remains an urgent need in clinical practice. Herein, a versatile composite microsphere with...

Cited by 22 publications

References 34 publications

RETRACTED ARTICLE: A convergent synthetic platform for dual anticancer drugs functionalized by reduced graphene nanocomposite delivery for hepatocellular cancer

RETRACTED ARTICLE: A convergent synthetic platform for dual anticancer drugs functionalized by reduced graphene nanocomposite delivery for hepatocellular cancer

Fabrication of novel PNIPAM@GO microspheres loaded with dual drugs featuring on‐demand drug release capability

Iron Oxide Nanoparticle-Based Hyperthermia as a Treatment Option in Various Gastrointestinal Malignancies

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