A Very Rare Case of Right Insular Lobe Langerhans Cell Histiocytosis (CD1a+) Mimicking Glioblastoma Multiforme in a Young Adult

Bartschi, Patrick; Luna, Enrique; González-López, Pablo; Abarca-Olivas, Javier; Herrero, J.; Costa, Estela; Payá, Artemio; Sales, Juan; Moreno, Pedro R.

doi:10.1016/j.wneu.2018.09.093

Cited by 3 publications

(3 citation statements)

References 23 publications

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“… alive Ranjan et al [ 41 ] BVS male 47 headache, aphasia primary total QT/RT,TMZ, nivolumab yes KI67(+) n.a. alive Richard et al [ 42 ] BVS male 28 seizures primary total QT/RT,TMZ no GFAP(+), OLIG2(+), ATRX(+), MKi67(+), MGMT(+) IDH-1(+),TP53(+), TERT(+) alive Rosen et al [ 43 ] BVS female 48 aphasia, hemiparesis primary partial QT/RT, TMZ, bevacizumab yes MGMT(−) IDH-1 wt(+) 13 months Wang et al [ 44 ] BVS male 4 headache, hemiparesis, vomiting primary total QT/RT, bevacizumab, nimotucimab, irinotecan yes GFAP(+),VIMENTIN(+),OLIG2(+), S-100(+)ATRX, MGMT(+),MKI67(+) TP53, IDH-1(+), SMAD3(+), SMARCB1(+) 8 years Bärtschi et al [ 45 ] BVS male 44 hemiparesis …”

Section: Resultsmentioning

confidence: 99%

Glioblastoma multiforme: a multi-omics analysis of driver genes and tumour heterogeneity

et al. 2021

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Glioblastoma (GBM) is the most aggressive and common brain cancer in adults with the lowest life expectancy. The current neuro-oncology practice has incorporated genes involved in key molecular events that drive GBM tumorigenesis as biomarkers to guide diagnosis and design treatment. This study summarizes findings describing the significant heterogeneity of GBM at the transcriptional and genomic levels, emphasizing 18 driver genes with clinical relevance. A pattern was identified fitting the stem cell model for GBM ontogenesis, with an upregulation profile for MGMT and downregulation for ATRX, H3F3A, TP53 and EGFR in the mesenchymal subtype. We also detected overexpression of EGFR, NES, VIM and TP53 in the classical subtype and of MKi67 and OLIG2 genes in the proneural subtype. Furthermore, we found a combination of the four biomarkers EGFR, NES, OLIG2 and VIM with a remarkable differential expression pattern which confers them a strong potential to determine the GBM molecular subtype. A unique distribution of somatic mutations was found for the young and adult population, particularly for genes related to DNA repair and chromatin remodelling, highlighting ATRX, MGMT and IDH1. Our results also revealed that highly lesioned genes undergo differential regulation with particular biological pathways for young patients. This multi-omic analysis will help delineate future strategies related to the use of these molecular markers for clinical decision-making in the medical routine.

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Section: Resultsmentioning

confidence: 99%

Glioblastoma multiforme: a multi-omics analysis of driver genes and tumour heterogeneity

et al. 2021

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“…LCH involving the hypothalamic-pituitary or skull is not uncommon, but involvement of the brain parenchyma, such as the frontotemporal lobe, is rare. As of January 2019, fewer than 30 cases have been reported in the PubMed database (Table 1 )[ 6 - 8 ]. We reviewed the relevant PubMed literature from 1990 to May 2021 and found 16 cases of brain parenchymal LCH with imaging data.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, PET/CT or PET/MRI seems to be more appropriate for evaluating this disease[ 16 ]. This is especially true for combined bone and lung lesions as some case without obvious symptoms are incidentally detected; they may be missed by relying solely on radiography or CT[ 8 ]. Several studies have confirmed the diagnostic value of systemic scans, such as PET/CT or PET/MRI for LCH[ 14 , 15 , 17 , 18 ].…”

Section: Discussionmentioning

confidence: 99%

Langerhans cell histiocytosis presenting as an isolated brain tumour: A case report

Liang¹,

Yang²,

Zhang³

et al. 2022

WJCC

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BACKGROUND Langerhans cell histiocytosis (LCH) is a rare proliferative histiocyte disorder. It can affect any organ or system, especially the bone, skin, lung, and central nervous system (CNS). In the CNS, the hypothalamic-pituitary is predominantly affected, whereas the brain parenchyma is rarely affected. LCH occurring in the brain parenchyma can be easily confused with glioblastoma or brain metastases. Thus, multimodal imaging is useful for the differential diagnosis of these intracerebral lesions and detection of lesions in the other organs. CASE SUMMARY A 47-year-old man presented with a headache for one week and sudden syncope. Brain computed tomography (CT) and magnetic resonance imaging showed an irregularly shaped nodule with heterogeneous enhancement. On 18 F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography/CT, a nodule with 18 F-FDG uptake and multiple cysts in the upper lobes of both lungs were noted, which was also confirmed by high-resolution CT. Thus, the patient underwent surgical resection of the brain lesion for further examination. Postoperative pathology confirmed LCH. The patient received chemotherapy after surgery. No recurrence was observed in the brain at the 12-mo follow-up. CONCLUSION Multimodal imaging is useful for evaluating the systemic condition of LCH, developing treatment plans, and designing post-treatment strategies.

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5-Aminolevulinic acid fluorescence in brain non-neoplastic lesions: a systematic review and case series

et al. 2022

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A Very Rare Case of Right Insular Lobe Langerhans Cell Histiocytosis (CD1a+) Mimicking Glioblastoma Multiforme in a Young Adult

Cited by 3 publications

References 23 publications

Glioblastoma multiforme: a multi-omics analysis of driver genes and tumour heterogeneity

Glioblastoma multiforme: a multi-omics analysis of driver genes and tumour heterogeneity

Langerhans cell histiocytosis presenting as an isolated brain tumour: A case report

5-Aminolevulinic acid fluorescence in brain non-neoplastic lesions: a systematic review and case series

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