A viable calf with trisomy 22

Mayr, B.; Krutzler, H; Auer, H.; Schleger, W.; Sasshofer, K; Glawischnig, Erich

doi:10.1159/000132109

Cited by 29 publications

(15 citation statements)

References 2 publications

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“…Viable trisomies have been reported in cattle, primarily for certain of the smaller chromosomes (33,34). Because the genetic content of U10 seems as great or greater than MMU 16, there may not be a possibility of viable trisomies for the U10 chromosome in cattle.…”

Section: Resultsmentioning

confidence: 99%

Evidence for the evolutionary origin of human chromosome 21 from comparative gene mapping in the cow and mouse.

Threadgill

Kraus²,

Krawetz³

et al. 1991

Proc. Natl. Acad. Sci. U.S.A.

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To determine the extent of conservation between bovine syntenic group U1O, human chromosome 21 (HSA 21), and mouse chromosome 16 (MMU 16), 11 genes were physically mapped by segregation analysis in a bovine-hamsuter hybrid somatic cell panel. The genes chosen for study span MMU 16 and represent virtually the entire q arm of HSA 21. Because the somatostatin gene (SST), an HSA 3/MMU 16 locus, was previously shown tube in U1O, the trnsferrin gene (TF), an HSA 3/MMU 9 marker, was also mapped to determine whether U10 contains any HSA 3 genes not represented on MMU 16. With the exception of the protamine gene PRMI

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Section: Resultsmentioning

confidence: 99%

Evidence for the evolutionary origin of human chromosome 21 from comparative gene mapping in the cow and mouse.

Threadgill

Kraus²,

Krawetz³

et al. 1991

Proc. Natl. Acad. Sci. U.S.A.

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“…1972). One case of trisomy 21 (Long, 1984) and one case of trisomy 22 (Mayr et al, 1985) were also reported. Of these 23 cases in cattle, 22 had severe congenital abnormalities and died in the neonatal period.…”

mentioning

confidence: 96%

Equine half sibs with an unbalanced X;15 translocation or trisomy 28

Power

1987

Cytogenet Genome Res

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Two unrelated chromosome abnormalities were found in equine half sibs. The proposita, Case 1, which was short in stature and infertile, had a de novo unbalanced X;15 translocation involving loss of Xp. Replication studies indicated that the translocated X was preferentially late replicating and that this late replication spread variably into the autosomal segment. Case 2, a half brother of the proposita, was short in stature, had cryptorchidism, and was trisomic for chromosome 28. Cytogenetic analysis of the dam, the sire of Case 1, and two other phenotypically normal half sibs revealed normal chromosome complements. Five further normal pregnancies were reported. The finding of two unrelated chromosome abnormalities is therefore probably fortuitous in this family. This is the first case of an unbalanced X-autosome translocation and the first case of an autosome trisomy to be reported in the horse.

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“…We now report that a cow trisomic for chromosome 22 is fertile. A viable female Fleckvieh (Simmental) calf with trisomy 22 was described in an earlier paper (Mayr et al, 1985). No evidence for mosaicism was detected in either lymphocyte or fibroblast metaphases (see Mayr et al, 1985).…”

mentioning

confidence: 97%

“…A viable female Fleckvieh (Simmental) calf with trisomy 22 was described in an earlier paper (Mayr et al, 1985). No evidence for mosaicism was detected in either lymphocyte or fibroblast metaphases (see Mayr et al, 1985). Unlike human chromosome 21. none of the three chromosomes 22 of our trisomic cow had a nucleolus organizer region.…”

mentioning

confidence: 97%