Objective: To identify adverse events associated with the vaccine and the Sars-Cov 2 virus in patients with facial aesthetic procedures (botulinum toxin type A and hyaluronic acid fillers) through a systematic literature review. Methodology: The Methodi Ordinatio methodology was used to select the portfolio of the most relevant articles in the area. The search was conducted in the PubMed database considering the period from 2019 to 2023. The final portfolio consisted of 33 articles. Results: The results show events that include filler site reactions, such as pain, edema, erythema, pruritus, bruising, infection, hypersensitivity, nodules, asymmetry, facial contour defects, skin discoloration, side effects, and tissue necrosis. Conclusion: The main contribution of this study was to share information on adverse events, considering the risks and implications arising from the vaccine and the Sars-Cov 2 virus along with facial aesthetic procedures, in order to guide injecting professionals on how to act in the market considering the pandemic.