A view of vascular stents.

Schatz, Richard

doi:10.1161/01.cir.79.2.445

Cited by 239 publications

(54 citation statements)

References 34 publications

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“…8 The implantation of genetically engineered endothelial cells on stent surfaces offers a potential means of preventing intimal hyperplasia because implanted endothelial cells would be in direct contact with the intima and could be engineered to secrete proteins capable of inhibiting intimal growth. Until the molecular basis of intimal hyperplasia is more clearly defined, however, this application will remain theoretical.…”

Section: Cellular Retention After Balloon Inflationmentioning

confidence: 99%

Seeding of intravascular stents with genetically engineered endothelial cells.

et al. 1989

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The use of intravascular stents may be limited by both local thrombosis and restenosis due to intimal proliferation. In an effort to provide solutions to these problems, we seeded stents with genetically engineered endothelial cells in vitro. Using retroviral-mediated gene transfer, we inserted the gene for either bacterial beta-galactosidase or human tissue-type plasminogen activator (t-PA) into cultured sheep endothelial cells. The endothelial cells were seeded onto stainless steel stents and grown until the stents were covered. Expression of intracellular beta-galactosidase and high level secretion of t-PA were demonstrated both before and after the transduced cells were seeded onto the stents. Eight stents were expanded by in vitro balloon inflation, with observation of the seeded endothelial layer both prior to and after expansion. Most of the endothelial cells remained on the stents after balloon inflation. We conclude that intravascular stents can be coated with a layer of genetically engineered endothelial cells that can be either specifically labeled or made to secrete high levels of a therapeutic protein. Much of the layer of genetically engineered cells remains after the expansion of the stent in vitro. In vivo implantation of stents coated with genetically engineered endothelial cells may allow 1) introduction of genetically engineered endothelial cells directly into the vascular wall and 2) improvement of stent function through localized delivery of anticoagulant, thrombolytic, or antiproliferative molecules.

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Section: Cellular Retention After Balloon Inflationmentioning

confidence: 99%

Seeding of intravascular stents with genetically engineered endothelial cells.

et al. 1989

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“…In atherosclerotic rabbits, Rob 19,26,[28][29][30][31][32][33] although the myofibroblasts may regress over time in the absence of atherogenic stimuli. 36 Once the wires of the stent have been incorporated into the vessel wall, the benign metallic alloy is relatively far from the luminal surface, away from the site of action of the atherogenesis during blood flow over the neointimal surface, so the eventual cellular reactions in the neointima may become less dependent on the configuration and composition of the stent.…”

Section: Discussionmentioning

confidence: 99%

Vascular stenting in normal and atherosclerotic rabbits. Studies of the intravascular endoprosthesis of titanium-nickel-alloy.

et al. 1990

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Percutaneous transluminal balloon angioplasty would be more effective if the rate of recurrent stenosis were reduced. To evaluate the prevention of restenosis after percutaneous transluminal angioplasty, intravascular endoprosthetic stents of titanium-nickel-alloy were implanted transluminally in seven normal and 21 atherosclerotic rabbits. In normal rabbits, a 3.5-mm diameter stent was implanted in the aorta and a 2.5 -mm diameter stent in the right iliac artery, which were followed with serial angiograms from 6 weeks (n = 7) to 8 months (n = 4). There was a mean stenosis of 13.1% in the 2.5-mm and 13.6% in the 3.5-mm stent. There was no significant narrowing compared with the adjacent control segments of artery; histopathology showed a thin, fibrous neointima with smooth muscle cells. Each atherosclerotic rabbit was balloon dilated at two separate stenotic sites; each site was 2.0 cm in length. The aortic site (with 28.8±13.8% mean stenosis [±SD]) was dilated with a 3.5-mm balloon, and the iliac site (with 36.5 14.2% stenosis) was dilated with a 2.5-mm balloon. In each site, an intravascular stent of corresponding diameter and 7-mm length was implanted in one half of the dilated segment, assigned randomly, and the other half served as the angioplasty control. Angiographically observed restenosis rates and the corresponding histopathology were similar in the atherosclerotic segments that had angioplasty alone versus the atherosclerotic segments that had angioplasty plus stenting. The mean neointimal thickness in the aortas and iliac arteries, respectively, measured 247+181 pum (±SD) and 218±77 jm after 6 weeks (n=8) versus 321+168 and 308+189 ,um after 20 weeks (n=5, p=NS). At 20 weeks follow-up, there was 29.1+29.8% (median, 16.4%) stenosis in the aortic stent versus 38.9±24.1% (median, 34.0%) stenosis in the percutaneous transluminal angioplasty control segment of aorta (n =5, p =NS) and 81.4+25.5% stenosis in the iliac artery stent versus 89.3+15.3% stenosis in the PTA control segment of the right iliac artery (n=5, p=NS). Comparing stenotic arterial segments treated with angioplasty alone with angioplasty plus intravascular stenting in the atherosclerotic rabbits showed that there was no significant difference in either the histopathologic changes or the restenosis rates. (Circulation 1990;81:667-683) There is a need for an endovascular prosthetic stent for the treatment of symptomatic arterial dissection and acute occlusion resulting from percutaneous transluminal angioplasty (PTA).

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“…In invasive cardiologic treatment, guide wires and cardiologic implants are generally made of wires and wire products made of stainless steel [1][2][3][4][5][6][7][8]. They should feature proper biotolerance, and what follows -high resistance to electrochemical corrosion in contact with blood.…”

Section: Introductionmentioning

confidence: 99%

Impact of Sterilisation and Strain Hardening in Drawing Process on Resistance to Electrochemical Corrosion of Wires Intended in Cardiology

Przondziono

Hadasik

Walke

et al. 2016

Archives of Metallurgy and Materials

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The study presents results of tests of impact of work hardening in cold drawing process, surface treatment and sterilisation on resistance to electrochemical corrosion of wires made of stainless steel X2CrNiMo 17-12-2 intended for cardiology. Potentiodynamic tests were performed on the ground of registered anodic polarisation curves in artificial plasma solution. Static uniaxial tension test made the ground for determination of strength characteristics of wires and the flow curve. Functions presenting the change of polarisation resistance according to strain applied in drawing process were selected. Test results show deterioration of corrosion properties of wires with work hardening. Surface modification of passivated surface caused increase of resistance of stainless steel wires to electrochemical corrosion, whereas sterilisation with pressurised water steam deteriorated that resistance.

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A view of vascular stents.

Cited by 239 publications

References 34 publications

Seeding of intravascular stents with genetically engineered endothelial cells.

Seeding of intravascular stents with genetically engineered endothelial cells.

Vascular stenting in normal and atherosclerotic rabbits. Studies of the intravascular endoprosthesis of titanium-nickel-alloy.

Impact of Sterilisation and Strain Hardening in Drawing Process on Resistance to Electrochemical Corrosion of Wires Intended in Cardiology

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