A View on Pathogenesis of ≪Vicious Cancer Progression Cycle≫

Abstract

Unrestricted tumor growth requires a permanent supply of glucose that can be obtained from cancer-stimulated hepatic glucose production and/or glucose redirecting from host insulin resistant tissues to cancer cells. This study proposes a mechanism based on metabolic and hormonal changes that may provoke glucose delivery to cancer cells through two interconnected "vicious cycles" whose continuous activity drives cancer progression. As follows from the proposed here feedback model, these "vicious cycles" result from cancer-mediated manipulation of host glucose sensors. The derived conclusions contribute to a better understanding of cancer pathogenesis and identifying potential therapeutic targets.

An exploratory human study of superstable homogeneous lipiodol–indocyanine green formulation for precise surgical navigation in liver cancer

“…However, due to the disease's rapid progression, many patients lost the opportunity for initial surgical resection when seeking treatment. Direct resection in cases in which there is a large tumor volume or a heavy tumor burden can cause excessive trauma, while the insufficient residual liver volume may lead to postoperative liver failure 3–5 . Therefore, to prolong relapse‐free and overall survival, it is essential to improve the overall prognosis of liver cancer by transforming initially unresectable patients into operable patients, palliative surgery into a radical resection, and the R1 resection into an R0 resection 6,7 …”

“…Direct resection in cases in which there is a large tumor volume or a heavy tumor burden can cause excessive trauma, while the insufficient residual liver volume may lead to postoperative liver failure. [3][4][5] Therefore, to prolong relapse-free and overall survival, it is essential to improve the overall prognosis of liver cancer by transforming initially unresectable patients into operable patients, palliative surgery into a radical resection, and the R1 resection into an R0 resection. 6,7 The concept of conversion therapy was first proposed in 1977 by Shafer and Selinkoff.…”

Precision Interventional Brachytherapy: A Promising Strategy Toward Treatment of Malignant Tumors

“…However, it is often difficult, if not impossible, to diagnose MT early. Accordingly, by the time tumors are found, patients are in the middle and late stage of the disease, and the rate of surgical resection and radical cure is thus low (9)(10)(11). Therefore, tools to improve the therapeutic effect of existing treatments on patients with MT is an urgent problem to be solved and a hot research topic at the moment.…”