A viologen-based conductive hydrogel enables iontophoresis devices powered by Mg biobattery

Zhou, Yang; Jiang, Shan; Ma, Xuenan; Mu, Yueming; Zhao, Jiaxin; Liang, Qing; Jia, Xiaoteng; Chao, Danming

doi:10.1016/j.cej.2023.143133

Cited by 6 publications

(4 citation statements)

References 36 publications

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“…The microstructure of these hydrogels has also been characterized by SEM after freeze-drying. As demonstrated in Figure 1d, the 2-EHP/PAM hydrogel exhibited a three- 17,18 the resultant EHP/PAM hydrogels exhibited architectural characteristics of hyperbranched macromolecules (EHP) as crosslinking centers in the hydrogel networks. This large-sized 3D crosslinker with more reactive sites could provide more polymeric chain entanglements, possibly resulting in a remarkable enhancement of mechanical properties.…”

Section: Synthesis and Structural Characterization Of Ehp/pam Hydrogelsmentioning

confidence: 98%

“…Hence, we developed viologen-based conductive hydrogels with the assistance of polyolefin, which exhibited desirable cytocompatible and antibacterial properties. The accurate modulation of electrostatic attraction between viologen and drug molecules effectuated the drug delivery and release upon the electric stimuli. , Nevertheless, the mechanical properties of these viologen-based conductive hydrogels cannot meet the requirements in their practical applications. Besides, to achieve a high utilization ratio of drugs, the ionic conductivity of viologen-based conductive hydrogels needs to be improved, which plays a vital role in the electro-stimulated drug delivery and release process.…”

Section: Introductionmentioning

confidence: 99%

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Conductive Viologen Hydrogel Based on Hyperbranched Polyamidoamine for Multiple Stimulus-Responsive Drug Delivery

Zhao

Zhou

Wang³

et al. 2023

ACS Appl. Mater. Interfaces

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The emergence of precision medicine and personalized pharmacotherapy has led to the development of advanced drug delivery systems that can respond to multiple stimuli. Conductive hydrogels have excellent electrical signal responsiveness and drug storage capabilities; however, current conductive hydrogels suffer from poor mechanical properties, low ionic conductivity, and high voltage. Herein, a covalently crosslinked viologen hydrogel was prepared using electroactive hyperbranched polyamidoamine (EHP) as the crosslinking center in a polymeric network. Attributed to its unique molecular architecture, this hydrogel exhibits improved mechanical properties (high tensile strength and desirable stretchability up to 1280%). Approvable ionic conductivity, biocompatibility, antibacterial properties, and wearable strain-sensing performance were also disclosed, ascribed to the participation of versatile viologen groups in the hydrogel structure. This hydrogel exhibited high efficiency in drug release (81.6%) at a lower voltage of −1.2 V. Moreover, fascinating pH-stimulus drug release behavior was also demonstrated in both acidic and alkalescent environments owing to the dramatic conformational transition of EHP. This work provides a new design strategy for conductive hydrogels for multiple stimulusresponsive drug delivery systems.

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Section: Synthesis and Structural Characterization Of Ehp/pam Hydrogelsmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Conductive Viologen Hydrogel Based on Hyperbranched Polyamidoamine for Multiple Stimulus-Responsive Drug Delivery

Zhao

Zhou

Wang³

et al. 2023

ACS Appl. Mater. Interfaces

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“…We have selected an alkylated quaternary pyridinium derivative, commonly known as viologen. − Viologen has been massively used owing to its multifaceted properties (ionic conductivity, photochromic and electrochromic properties, antibacterial properties, and so on). Its backbone has been included in dendrimers, polymers, and covalent organic framework, and more recently, it has been also embedded in hydrogels and/or grafted on other related nanostructures. − In most cases, these materials showed electro-sensitive properties ( e.g. , conductive hydrogels suitable for transdermal bioelectronics devices, wound dressing, electro-stimulated drug delivery, etc.)…”

Section: Introductionmentioning

confidence: 99%

“…, conductive hydrogels suitable for transdermal bioelectronics devices, wound dressing, electro-stimulated drug delivery, etc.) coupled to good antibacterial activity, with a more intriguing structure–reactivity relationship. ,,− ,− In a complementary fashion, mechanically tailorable double network chitosan-based hydrogels have also emerged as multitask functional biomaterials. − …”

Section: Introductionmentioning

confidence: 99%

Viologen Cross-Linked Chitosan Hydrogel as Biobased Antiseptic Surface-Coating Materials

Boundor,

Bielska,

Katir

et al. 2023

ACS Appl. Polym. Mater.

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The recent COVID-19 pandemic has triggered an avalanche of research seeking powerful antibacterial and antiviral material-based technologies. Herein, we report the cross-linking of chitosan fishery waste using three different aldehyde-terminated viologens to design iono-functional, shapeable biobased antiseptic hydrogels. Structural investigation has corroborated the presence of the cross-linked cationic 4,4′-bipyridium motif inside and confirmed its accessibility to the guests through chemical reduction. The network can be moreover cross-linked with the simultaneous entrapment of gold, silver, and copper nanoparticles, enabling the accommodation of additional synergistic functionalities inside of the framework. The multifaceted character of the resulting soft hydrogel network is illustrated through its use as a spray to coat glassy surfaces, its casting to deliver transparent and flexible micrometer-thick films, and its coagulation to provide open porous microspheres. Interesting antibacterial activity has been noticed for the cross-linking films, owing to the presence of cationic viologen, with the inhibitory effect being more significant for negative-gram bacteria compared to positive-gram bacteria. Within the two series, the trend in the biological response correlates with increasing the number of the viologen units and/or the engaged molar ratio with respect to native chitosan films. A maximum inhibitory effect of 85% was recorded for negative-gram bacteria, while 50% inhibition was the best performance reached for positive-gram bacteria. Significant amplification of the antibacterial activity has been further noticed using transparent films entrapping a tiny amount of metal nanoparticles (gold, silver, and gold), outperforming holistically those entrapping metal nanoparticles without cross-linking. Specifically, gold nanoparticles grown within the reticular viologen-containing framework enabled the highest antibacterial activity (98% inhibition for negative-gram bacteria and 75% inhibition for positive-gram bacteria), contrasting with a very negligible side effect in terms of hemolytic activity. The straightforwardness, biodegradability, and cost-effectiveness of the disclosed approach open great possibilities toward large-scale use as an antiseptic spray for surface-coating against nosocomial infections.

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Synergistic Strategies of Biomolecular Transport Technologies in Transdermal Healthcare Systems

Han,

Choi,

Kang

2024

Adv Healthcare Materials

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Transdermal healthcare systems have gained significant attention for their painless and convenient drug administration, as well as their ability to detect biomarkers promptly. However, the skin barrier limits the candidates of biomolecules that can be transported, and reliance on simple diffusion poses a bottleneck for personalized diagnosis and treatment. Consequently, recent advancements in transdermal transport technologies have evolved toward active methods based on external energy sources. Multiple combinations of these technologies have also shown promise for increasing therapeutic effectiveness and diagnostic accuracy as delivery efficiency is maximized. Furthermore, wearable healthcare platforms are being developed in diverse aspects for patient convenience, safety, and on‐demand treatment. Herein, a comprehensive overview of active transdermal delivery technologies is provided, highlighting the combination‐based diagnostics, therapeutics, and theragnostics, along with the latest trends in platform advancements. This offers insights into the potential applications of next‐generation wearable transdermal medical devices for personalized autonomous healthcare.

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A viologen-based conductive hydrogel enables iontophoresis devices powered by Mg biobattery

Cited by 6 publications

References 36 publications

Conductive Viologen Hydrogel Based on Hyperbranched Polyamidoamine for Multiple Stimulus-Responsive Drug Delivery

Conductive Viologen Hydrogel Based on Hyperbranched Polyamidoamine for Multiple Stimulus-Responsive Drug Delivery

Viologen Cross-Linked Chitosan Hydrogel as Biobased Antiseptic Surface-Coating Materials

Synergistic Strategies of Biomolecular Transport Technologies in Transdermal Healthcare Systems

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