2020
DOI: 10.1038/s42003-020-0970-9
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A virophage cross-species infection through mutant selection represses giant virus propagation, promoting host cell survival

Abstract: Virus adaptation to new hosts is a major cause of infectious disease emergence. This mechanism has been intensively studied in the context of zoonotic virus spillover, due to its impact on global health. However, it remains unclear for virophages, parasites of giant viruses and potential regulators of microbial communities. Here, we present, for the first time to our knowledge, evidence of cross-species infection of a virophage. We demonstrated that challenging the native population of Guarani virophage with t… Show more

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Cited by 18 publications
(11 citation statements)
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“…Therefore, we have not presently confirmed that there is a MIMIVIRE-like system in the cotonvirus genome as in the lineage A mimivirus genome ( 15 ). Additionally, we did not detect sequences highly homologous with those of virophages Sputnik ( 27 ) or Guarani ( 28 ) in the cotonvirus genome.…”
Section: Resultsmentioning
confidence: 57%
“…Therefore, we have not presently confirmed that there is a MIMIVIRE-like system in the cotonvirus genome as in the lineage A mimivirus genome ( 15 ). Additionally, we did not detect sequences highly homologous with those of virophages Sputnik ( 27 ) or Guarani ( 28 ) in the cotonvirus genome.…”
Section: Resultsmentioning
confidence: 57%
“…Virophages can play key roles in host defense against their associated giant viruses (Table 1; Berjón-Otero et al, 2019;Blanc et al, 2015;Fischer, 2015;Fischer & Hackl, 2016;Hackl et al, 2021;Koonin & Krupovic, 2016;Mougari et al, 2019Mougari et al, , 2020. While to the best of our knowledge, virophage-mediated defense has not yet been observed in ciliates, it is reasonable to speculate that it occurs.…”
Section: T R a Nsf Er Of V I R A L Dna I N To T H E C I L I At E Ge N...mentioning
confidence: 99%
“…2020 ). Virophages can parasitize co-infecting giant DNA viruses in a host and may provide adaptive anti-giant virus defence in unicellular eukaryotes ( Fischer and Hackl 2016 ; Duponchel and Fischer 2019 ; Mougari et al. 2020 ).…”
Section: Introductionmentioning
confidence: 99%