Among all quips of the famous American writer, Mark Twain (Samuel Langhorne Clemens), my two favourites are "Lies, damned lies, and statistics" and" "It is best to read the weather forecasts before we pray for rain". I find these two particularly fascinating because they remind me of the paradox and the slippery slope of predicting the future. I think we all agree that pandemic has humiliatingly shown us that the future is unpredictable. None of our complex and intelligent models that have been built over years of data could predict the recent pandemic. However, we still use them to understand the spread of the virus, to predict the results of interventions, and to make science-led policies. Isn't it ironic? This editorial looks at the paradox of prediction, the certainty of having uncertainly, and the predictability of having an unpredictable future.