“…Therefore, the application allows the student, in addition to observing, to interact and manipulate the cell to improve its understanding and study. For the virtual world of the human cell, the study of it has been integrated based on the simulation of a blood flow; that is, this environment can perform a simulation of healthy human blood [9], where 3D cell models are integrated such as red blood cells, white blood cells, and platelets, allowing to modify red blood cells by sickle cells (sickle cell disease, macrocytosis, and dehydrated red blood cells), to allow the student to visualize and identify this type of anomalies. Within the virtual world of the animal and plant cell, a space is built that allows validating the acquired knowledge; that is why a puzzle based on a mini-game is integrated that allows the student to recognize each of the cell components as requested by the application, after which, once the learning challenge is completed, it is averaged based on the hits to show the student what they have learned about the proposed study.…”