A `virus-free' cell line derived from a patient with infectious mononucleosis

Abstract

A continuous cell culture line, derived from a nurse with infectious mononucleosis, is described. Electron microscopic and immunofluorescent examination suggested that it was substantially free from detectable complete virus particles, although the presence of a soluble complement-fixing antigen showed the persistence of other antigenic components of the EB virus.

Antibodies to Epstein-Barr and other viruses in children with acute lymphoblastic leukaemia

“…EB CF antibodies, which differ in several respects from EB virus capsid antigen antibodies (Marston et al, 1972), develop regularly after infectious mononucleosis. These CF antibodies develop slowly and, though sometimes detectable in individuals with active infectious mononucleosis, are normally only detectable after some months.…”

“…. Our observations that in infectious mononucleosis antibodies to a soluble complement-fixing antigen specified by the EB virus develop much later than antibodies to the EB virus capsid antigen (from which it is quite distinct -Marston et al, 1972) allow a somewhat more extensive interpretation to be made of serological results than that based upon the estimation of one type of antibody only.…”