A visible-light activated ROS generator multilayer film for antibacterial coatings

Gill, Arshdeep Kaur; Shah, Sanchita; Yadav, Pranjali; Shanavas, Asifkhan; Neelakandan, Prakash P.; Patra, Debabrata

doi:10.1039/d2tb01454h

J. Mater. Chem. B

2022

DOI: 10.1039/d2tb01454h

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A visible-light activated ROS generator multilayer film for antibacterial coatings

Arshdeep Kaur Gill

Sanchita Shah²,

Pranjali Yadav³

et al.

Abstract: The current scenario of antibiotic-resistant bacteria and pandemics caused by viruses makes research in the area of antibacterial and antiviral materials and surfaces more urgent than ever. In this regard,...

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2024

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Cited by 2 publications

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Visible Light Activation of Virucidal Surfaces Empowered by Pro‐Oxidant Carbon Dots

Malfatti,

Poddighe,

Stagi

et al. 2024

Adv Funct Materials

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The scientific community is actively engaged in the development of innovative nanomaterials with broad‐spectrum virucidal properties, particularly those capable of producing reactive oxygen species (ROS), to combat upcoming pandemics effectively. The generation of ROS capable of inhibiting viral activity on high‐touch surfaces can prove an effective means of reducing pathogenic and viral infections, while avoiding the exacerbation of antibiotic resistance resulting from the extensive use of chemical disinfectants. Carbon dots (C‐dots), in particular, are a class of nanomaterials that under specific conditions is able to generate reactive species. They are, therefore, excellent candidates for fabricating light‐activated functional antiviral devices. Pro‐oxidant C‐dots have been developed via microwave synthesis using an amino acid, glycine (Gly), and 1,5‐diaminonaphtalene (DAN) as precursors. The formation of C‐dots has been obtained by reacting the precursors in microwave using two different acid catalysts, H3BO3 or HCl. The HCl catalyst promotes the formation of a copolymer while using H3BO3 the precursors preferentially self‐condense. The boron‐catalyzed samples have shown to contain radical centers whose intensity increases upon illumination by UV and also visible light. They also show the capability of generating singlet oxygen through energy transfer to oxygen molecules when irradiated. The C‐dots exhibit effective virucidal activity and have been tested in vitro using two different variants of SARS‐CoV‐2, the original strain, and Omicron. Antiviral C‐dots have been finally used to functionalize a model surface, inducing a strong virucidal activity against the SARS‐CoV‐2 coronavirus with both ultraviolet (UV) and visible (VL) light.

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Visible Light Activation of Virucidal Surfaces Empowered by Pro‐Oxidant Carbon Dots

Malfatti,

Poddighe,

Stagi

et al. 2024

Adv Funct Materials

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Biomaterials-based phototherapy for bacterial infections

Wu,

Xu,

et al. 2024

Front. Pharmacol.

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Bacterial infections and antibiotic resistance are global health problems, and current treatments for bacterial infections still rely on the use of antibiotics. Phototherapy based on the use of a photosensitizer has high efficiency, a broad spectrum, strong selectivity, does not easily induce drug resistance, and is expected to become an effective strategy for the treatment of bacterial infections, particularly drug-resistant infections. This article reviews antimicrobial strategies of phototherapy based on photosensitizers, including photodynamic therapy (PDT), photothermal therapy (PTT), and their combination. These methods have significant application potential in combating multi-drug-resistant bacterial and biofilm infections, providing an alternative to traditional antibiotics and chemical antibacterial agents.

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A visible-light activated ROS generator multilayer film for antibacterial coatings

Abstract: The current scenario of antibiotic-resistant bacteria and pandemics caused by viruses makes research in the area of antibacterial and antiviral materials and surfaces more urgent than ever. In this regard,...

Cited by 2 publications

References 58 publications

Visible Light Activation of Virucidal Surfaces Empowered by Pro‐Oxidant Carbon Dots

Visible Light Activation of Virucidal Surfaces Empowered by Pro‐Oxidant Carbon Dots

Biomaterials-based phototherapy for bacterial infections

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