A Visible‐Light‐Regulated Chloride Transport Channel Inspired by Rhodopsin

Quan, Jiaxin; Zhu, Fang; Dhinakaran, Manivannan Kalavathi; Yang, Yingying; Johnson, Robert P.; Li, Haibing

doi:10.1002/ange.202012984

Cited by 3 publications

(4 citation statements)

References 46 publications

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“…Research into these visible light-response membrane channels is significant for comprehending signal transduction in biological functions and their valuable applications in fostering interdisciplinary research endeavors. Li et al [223] presented a clever chloride ion (Cl − ) transport membrane channel that relied on supramolecular interactions. They harnessed a natural retinal chromophore (Guest24, 25), which responds to visible light, as a guest molecule in their artificial channels.…”

Section: Artificial Nanochannelmentioning

confidence: 99%

Applications of Supramolecular Polymers Generated from Pillar[n]arene-Based Molecules

Li,

Jin,

Zhu

et al. 2023

Polymers

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Supramolecular chemistry enables the manipulation of functional components on a molecular scale, facilitating a “bottom-up” approach to govern the sizes and structures of supramolecular materials. Using dynamic non-covalent interactions, supramolecular polymers can create materials with reversible and degradable characteristics and the abilities to self-heal and respond to external stimuli. Pillar[n]arene represents a novel class of macrocyclic hosts, emerging after cyclodextrins, crown ethers, calixarenes, and cucurbiturils. Its significance lies in its distinctive structure, comparing an electron-rich cavity and two finely adjustable rims, which has sparked considerable interest. Furthermore, the straightforward synthesis, uncomplicated functionalization, and remarkable properties of pillar[n]arene based on supramolecular interactions make it an excellent candidate for material construction, particularly in generating interpenetrating supramolecular polymers. Polymers resulting from supramolecular interactions involving pillar[n]arene find potential in various applications, including fluorescence sensors, substance adsorption and separation, catalysis, light-harvesting systems, artificial nanochannels, and drug delivery. In this context, we provide an overview of these recent frontier research fields in the use of pillar[n]arene-based supramolecular polymers, which serves as a source of inspiration for the creation of innovative functional polymer materials derived from pillar[n]arene derivatives.

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Section: Artificial Nanochannelmentioning

confidence: 99%

Applications of Supramolecular Polymers Generated from Pillar[n]arene-Based Molecules

Li,

Jin,

Zhu

et al. 2023

Polymers

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“…Li recently fabricated a visible‐light‐regulated chloride transport channel based on the host–guest system of an ethyl‐urea‐derived P6A (urea‐P6) host and a photoisomerizable retinal guest (Figure 7b). [ 69 ] The retinal structure changed from an all‐ trans isomer to an 11‐ cis isomer under visible light. [ 70 ] The hydrophilic urea‐P6 molecule was introduced in the nanochannel through host–guest self‐assembly with the all‐ trans ‐retinal molecule under darkness.…”

Section: Binary Host–guest Chemistrymentioning

confidence: 99%

mentioning

confidence: 99%

Photoresponsive Solid Nanochannels Membranes: Design and Applications

Cheng

Zhang

Min

et al. 2021

Small

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Biological channels have fundamental roles in the metabolism of organisms by precisely regulating the transport of molecules and ions, which is necessary to maintain the normal activity of the living body. [1,2] A typical example of biological channelrhodopsins that serve as sensory photoreceptors would function as a signal transmission medium. [1] Inspired by biological channels, scientists have built various artificial solid Light stimuli have notable advantages over other environmental stimuli, such as more precise spatial and temporal regulation, and the ability to serve as an energy source to power the system. In nature, photoresponsive nanochannels are important components of organisms, with examples including the rhodopsin channels in optic nerve cells and photoresponsive protein channels in the photosynthesis system of plants. Inspired by biological channels, scientists have constructed various photoresponsive, smart solidstate nanochannels membranes for a range of applications. In this review, the methods and applications of photosensitive nanochannels membranes are summarized. The authors believe that this review will inspire researchers to further develop multifunctional artificial nanochannels for applications in the fields of biosensors, stimuli-responsive smart devices, and nanofluidic devices, among others.

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“…In nature, proteins prove to be effective in confining photoresponsive molecules and providing stable microenvironment for their photosensitisation. [11,12] For example, the function of rhodopsin as a visible light responsive ion transport channel depends on the conformational isomerisation between 11-cis-retinal and all-trans-retinal within the binding pocket of a specific protein. [13] Inspired by natural design, researchers have recently utilised protein-encapsulation strategy as a new means to fabricate fluorescence photoswitch systems.…”

Section: Introductionmentioning

confidence: 99%

Site‐specific fabrication of gold nanocluster‐based fluorescence photoswitch enabled by the dual roles of albumin proteins

Zhong

Yan

et al. 2022

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Fluorescence photoswitch is becoming increasingly desirable for many applications, but its controllable fabrication still remains challenging yet. In this paper, a new strategy is proposed to fabricate fluorescence photoswitch by harnessing dual roles of albumin proteins as both photochrome carriers and biotemplates of fluorophore. As an example, we demonstrated the successful fabrication of a fluorescence photoswitch by incorporating both the photochromic diarylethene dye (CMTE) and red‐emitting fluorescent gold nanoclusters (AuNCs) into the specific domains of bovine serum albumin (BSA) in a highly controllable manner. Detailed spectral and photophysical characterisation showed that CMTE well‐retains the photochromic properties within the CMTE–BSA–AuNC construct, although its photoconversion rate is slightly retarded. Different from previously reported photoswitches, the fluorescence of the present system is mainly modulated via the inner filter effect (IFE) mechanism, which exhibits high switching efficiency with an on–off ratio up to 90%, reversible fluorescence response and good antifatigue performance. This work provides a new, generable albumin protein‐assisted strategy of fabricating advanced fluorescence photoswitch, which can find wide applications in biological, optical and information fields.

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A Visible‐Light‐Regulated Chloride Transport Channel Inspired by Rhodopsin

Cited by 3 publications

References 46 publications

Applications of Supramolecular Polymers Generated from Pillar[n]arene-Based Molecules

Applications of Supramolecular Polymers Generated from Pillar[n]arene-Based Molecules

Photoresponsive Solid Nanochannels Membranes: Design and Applications

Site‐specific fabrication of gold nanocluster‐based fluorescence photoswitch enabled by the dual roles of albumin proteins

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