By the end of 2020, over 1.8 million Americans will be diagnosed with cancer and 600,000 will die from the disease. Despite experiencing lower incidence rates of cancer compared to non-Hispanic Whites, the Hispanic population in the United States faces a number of barriers to care, which may result in more involved, costlier, and potentially less successful treatments. Hispanic men in particular experience disproportionate cancer-related health disparities compared to other racial and ethnic groups and Hispanic women. Hispanic men cancer survivors (HMCS) have unique supportive care needs and use a variety of coping mechanisms, which remain largely unaccounted for and unaddressed. This chapter presents a brief description of cancer epidemiology and relevant disparities in diagnosis and care for the Hispanic population in the United States. It also explores merging research centered on preliminary data about the supportive care needs of HMCS and concludes with recommendations for public health research and practice.