A Walk-and-Eat Intervention Improves Outcomes for Patients With Esophageal Cancer Undergoing Neoadjuvant Chemoradiotherapy

Xu, Yu Juan; Cheng, Jason Chia‐Hsien; Lee, Jang-Ming; Huang, Pei-Ming; Huang, Guan‐Hua; Chen, Chia‐Hui

doi:10.1634/theoncologist.2015-0178

Cited by 76 publications

(117 citation statements)

References 36 publications

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“…During chemoradiotherapy, the group that received the walk-and-eat intervention had 100-m less decline than controls in walk distance, 3 kg less decrease in handgrip strength, and 2.7 kg less reduction in body weight. Moreover, the experimental group had significantly reduced rates of intravenous nutritional support and wheel chair use [110]. Another randomized trial tested the effects of an interdisciplinary nutrition support team on clinical and hospitalized outcomes of esophageal cancer patients receiving concurrent chemoradiotherapy.…”

Section: Nutritional Interventions During Chemoradiotherapymentioning

confidence: 99%

Nutritional Management of Esophageal Cancer Patients

Schizas¹,

Lidoriki²,

Moris³

et al. 2017

Esophageal Abnormalities

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Esophageal cancer is associated with malnutrition in the vast majority of patients. This phenomenon is partly attributed to the disease process itself, the location of the tumor and other factors, such as dysphagia which is often accentuated due to chemotherapy/ radiotherapy treatment or surgical intervention. The poor nutritional status of these patients is often related to the presence of cancer cachexia, altered metabolism, and tissue wasting. Malnutrition in this patient population affects quality of life, worsens patient's tolerance to chemotherapy and accounts for lower survival. Nutritional management of these patients includes both proper nutritional assessment and support and might prevent, to a certain extent, the manifestation of malnutrition-related consequences. The purpose of this article is to review the current literature in order to focus on the etiology and diagnosis of malnutrition in esophageal cancer patients, emphasizing also on the optimal nutritional support during multimodality treatment.

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Section: Nutritional Interventions During Chemoradiotherapymentioning

confidence: 99%

Nutritional Management of Esophageal Cancer Patients

Schizas¹,

Lidoriki²,

Moris³

et al. 2017

Esophageal Abnormalities

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“…Patients with these cancers who have metastatic disease should be treated with the anti-HER2 monoclonal antibody trastuzumab in addition to a fluoropyrimidine and platinum agent. 22 Current initial chemotherapy will produce a meaningful response in only about 20%-30% of patients. The duration of tumor responses is usually around four to six months.…”

Section: Chemotherapy and Chemoradiationmentioning

confidence: 99%

Cancer of the Esophagus

Kwait¹,

Pieters²,

Toke³

et al. 2019

Cancer Concepts: A Guidebook for the Non-Oncologist

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Esophageal cancer is classified histologically as squamous cell carcinoma or adenocarcinoma. 1 2. Worldwide, squamous cell carcinoma is the more common type of cancer of the esophagus. 3. The incidence of esophageal adenocarcinoma has been rising in the developed nations, apparently due to its association with gastroesophageal reflux disease, obesity and Barrett's esophagus. 4. Squamous cell carcinoma is more common in a setting of tobacco and alcohol use. 5. The tissue diagnosis of esophageal carcinoma is made by endoscopy with biopsy. 6. Staging workup is classically performed using endoscopy and/or barium swallow under fluoroscopy, CT and PET/CT. 7. The American Joint Committee on Cancer (AJCC) tumor node metastasis (TNM) classification system is used to stage esophageal cancer. 8. Multimodality treatment for local control and palliation is almost always indicated if the patient is able to tolerate it. Most esophageal carcinomas present at a fairly advanced stage because symptoms occur late in many patients, but early diagnosis improves outcomes. 1 9. The prognosis for most patients with esophageal cancer remains poor. Treatment is often focused on symptom relief.

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“…Treatment-related anaemia, pneumonitis and physical inactivity might have reduced Doris’ exercise tolerance, particularly during her recent hospital admission [3,44]. Studies support exercise alongside chemoradiotherapy therapy [45 ▪▪ ]. Although no study has purposefully selected cachectic patients [46], exercise has an anti-inflammatory effect [47] and can help maintain function.…”

Section: Case #2: Commenced Radical Chemoradiotherapymentioning

confidence: 99%

Practical multimodal care for cancer cachexia

Maddocks

Hopkinson

Conibear

et al. 2016

Current Opinion in Supportive &Amp; Palliative Care

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Purpose of reviewCancer cachexia is common and reduces function, treatment tolerability and quality of life. Given its multifaceted pathophysiology a multimodal approach to cachexia management is advocated for, but can be difficult to realise in practice. We use a case-based approach to highlight practical approaches to the multimodal management of cachexia for patients across the cancer trajectory.Recent findingsFour cases with lung cancer spanning surgical resection, radical chemoradiotherapy, palliative chemotherapy and no anticancer treatment are presented. We propose multimodal care approaches that incorporate nutritional support, exercise, and anti-inflammatory agents, on a background of personalized oncology care and family-centred education. Collectively, the cases reveal that multimodal care is part of everyone's remit, often focuses on supported self-management, and demands buy-in from the patient and their family. Once operationalized, multimodal care approaches can be tested pragmatically, including alongside emerging pharmacological cachexia treatments.SummaryWe demonstrate that multimodal care for cancer cachexia can be achieved using simple treatments and without a dedicated team of specialists. The sharing of advice between health professionals can help build collective confidence and expertise, moving towards a position in which every team member feels they can contribute towards multimodal care.

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A Walk-and-Eat Intervention Improves Outcomes for Patients With Esophageal Cancer Undergoing Neoadjuvant Chemoradiotherapy

Cited by 76 publications

References 36 publications

Nutritional Management of Esophageal Cancer Patients

Nutritional Management of Esophageal Cancer Patients

Cancer of the Esophagus

Practical multimodal care for cancer cachexia

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