A water-cooled transcranial magnetic stimulation coil

Pridmore, Saxby; Ang, G.B.

doi:10.1016/j.brs.2007.08.002

Cited by 4 publications

(1 citation statement)

References 2 publications

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“…There are several physical and technical challenges in scaling down to small-scale TMS coils. For example, applying large currents will lead to overheating [19, 28, 43, 44]. Furthermore, there is a lack of clarity on what parameters should be optimised in a small-scale coil design [19, 45].…”

Section: Introductionmentioning

confidence: 99%

Design and demonstration in vitro of a mouse-specific Transcranial Magnetic Stimulation coil

Khokhar

Voss

Steyn-Ross

et al. 2020

Preprint

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BackgroundTranscranial Magnetic Stimulation (TMS) is a technique used to treat different neurological disorders non-invasively. A pulsed current to a coil induces an E-field. Underlying biophysical effects of TMS are unclear. Therefore, animal experiments are needed; however, making small TMS coils suitable for mice is difficult because their field strengths are much lower than for human sized coils. Objectives/HypothesisWe aimed to design and demonstrate a mouse-specific coil that can generate high and focused E-field. MethodsWe designed a tapered TMS coil of 50 turns of 0.2 mm diameter copper wire around a 5 mm diameter tapered powdered iron core and discharged a 220 µF capacitor at 50 V through it. We measured B-field with a Hall probe and induced E-field with a wire loop. We measured temperature rise with a thermocouple. We applied 1200 pulses of cTBS and iTBS to mouse brain slices and analysed how spontaneous electrical activity changed. ResultsThe coil gave maximum B-field of 760 mT and maximum E-field of 32 V/m, 2 mm below the coil, at 50 V power supply with a temperature increase of 20 degrees after 1200 pulses of cTBS. cTBS reduced frequency of spontaneous activity up to 20 minutes after stimulation and iTBS increased frequency of up to 20 minutes after stimulation. No frequency changes occurred after 20 minutes. No frequency changes in amplitude of spontaneous events were found. ConclusionThe design generated focused fields strong enough to modulate brain activity in vitro.

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