2010
DOI: 10.1016/j.jconrel.2010.01.005
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A water gradient can be used to regulate drug transport across skin

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Cited by 83 publications
(113 citation statements)
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References 54 publications
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“…All solvents investigated induce mobility in SC components. The changes in the proportion between fluid SC and solid lipids and proteins can have a large impact on the macroscopic properties of the SC, including transport barrier function, flexibility, and softness (2,6,13,16,17). The observed effects vary with the polarity of the solvent, its concentration, and SC hydration conditions.…”
Section: Extraction Of Mobile Lipids From Sc Due To Exposure To Excessmentioning
confidence: 99%
See 1 more Smart Citation
“…All solvents investigated induce mobility in SC components. The changes in the proportion between fluid SC and solid lipids and proteins can have a large impact on the macroscopic properties of the SC, including transport barrier function, flexibility, and softness (2,6,13,16,17). The observed effects vary with the polarity of the solvent, its concentration, and SC hydration conditions.…”
Section: Extraction Of Mobile Lipids From Sc Due To Exposure To Excessmentioning
confidence: 99%
“…The macroscopic material properties of the SC barrier membrane naturally depend on the molecular properties of its building blocks. In particular, transport properties as well as mechanical properties and water-holding capacity can be altered by changing the balance between solid and fluid structures in the complex SC material (13,14,(16)(17)(18)(19). Increasing fluidity is expected to lead to higher solubility and a higher diffusion coefficient for most added compounds, and thus increased effective SC permeability (14,18,19).…”
mentioning
confidence: 99%
“…This is shown in Figure 3B as linear dependencies between J ss & ε, with R 2 values of 0.6 and 0.8 for membranes exposed to Cream A and Cream B, respectively. A higher ε value indicates that the extracellular lamellar lipid matrix in the stratum corneum has an increased fraction of lipids in the fluid state, and in many studies it has been shown that molecular diffusion in lipids is facilitated by a transition from the crystalline to the liquid crystalline state [22][23][24].…”
Section: Discussionmentioning
confidence: 99%
“…Deformable liposomes and ethosomes improve skin delivery (permeation and deposition) of the model hydrophilic drug ketotifen (KT) fumarate, with greater improvement of deposition than permeation. 31) The x-z axis serial images from CLSM (Fig. 5) show the different penetration depths of NaFI and Rh-PE from PLs with d-limonene.…”
Section: Fig 1 Atomic Force Microscopy (Amf) Images Of (A) Cls (B)mentioning
confidence: 98%