A water soluble Al3+ selective colorimetric and fluorescent turn-on chemosensor and its application in living cell imaging

Abstract

An efficient water soluble fluorescent Al(3+) receptor, 1-[[(2-furanylmethyl)imino]methyl]-2-naphthol (1-H) was synthesized and characterized by physico-chemical and spectroscopic tools along with single crystal X-ray crystallography. High selectivity and affinity of 1-H towards Al(3+) in HEPES buffer (DMSO/water: 1/100) of pH 7.4 at 25 °C showed it to be suitable for detection of intracellular Al(3+) by fluorescence microscopy. Metal ions, viz. alkali (Na(+), K(+)), alkaline earth (Mg(2+), Ca(2+)), and transition-metal ions (Ni(2+), Zn(2+), Cd(2+), Co(2+), Cu(2+), Fe(3+), Cr(3+/6+), Hg(2+)) and Pb(2+), Ag(+) did not interfere. The lowest detection limit for Al(3+) was calculated to be 6.03 × 10(-7) M in 100 mM HEPES buffer (DMSO/water: 1/100). Theoretical calculations have also been included in support of the configuration of the probe-aluminium complex.

A simple triazole-based “turn on” fluorescent sensor for Al3+ ion in MeCN–H2O and F− ion in MeCN

“…The acidic medium induces dissociation of the complex and protonation of the ligand; therefore there is decrease in the emission intensity. At higher pH values (pH 47.5) the OH À ions and NTA compete for the Al 3 þ ion, which increases the formation of the metal ion precipitation, thereby lowering the emission intensity [30]. Therefore, using NTA to detect Al 3 þ ion is shown to be feasible within a pH range (5.5-7.5).…”

A chromone Schiff-base as Al(III) selective fluorescent and colorimetric chemosensor

“…such as Li + , Na + , K + , Cr 3+ , Cu 2+ , Hg 2+ , Pb 2+ , Ba 2+ , Fe 3+ , Fe 2+ , Mn 2+ , Co 2+ , Ca 2+ , Ag + , Cd 2+ , Ni 2+ , Mg 2+ , Zn 2+ did not give rise to significant color changes. These results suggest that MCIH could be served as a potential "naked-eye" sensor selective for Al 3+(Figure 2)[22][23][24][25].3.2. Emission studiesMCIH forms colorless and nonfluorescent solutions in organic solvents, including ethanol, methanol, acetonitrile, (dimethyl formamide) DMF, (tetrahydrofuran) THF and (dimethylsulfoxide) DMSO.…”

Selective fluorescent sensor for Al3+ using a novel quinoline derivative in aqueous solution

“…Following oxygen and silicon, aluminum is the third most abundant of all elements and is found in most animal and plant tissues as well as in natural water because of acidic rain and human activities [1][2][3][4][5]. Nevertheless, as a non-essential and toxic element for living systems, the incremental increase of Al 3+ concentrations is detrimental to plant growth.…”