A water-soluble extract from Cucurbita moschata shows anti-obesity effects by controlling lipid metabolism in a high fat diet-induced obesity mouse model

Choi, Hyeong In; Eo, Haekwan; Park, Kyoungcheol; Jin, Myung; Park, Eun Jin; Kim, Seung‐Chul; Park, Jeong Euy; Kim, Sun‐Young

doi:10.1016/j.bbrc.2007.05.107

Cited by 89 publications

(59 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The hypocholesterolemic effect of CEO has been ascribed to inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (Srinivasan and Sambaiah, 1991), the rate controlling enzyme of the cholesterol synthetic pathway. During the screening of a variety of plant sources for their anti-obesity activity, Choi et al (2007) found that a water-soluble extract, named PG105, prepared from stem parts of Cucurbita moschata, contains potent anti-obesity activities in a high fat diet-induced obesity mouse model. In this animal model, increases in body weight and fat storage were suppressed by 8-week oral administration of PG105 at 500 mg kg  1 , while the overall amount of food intake was not affected.…”

Section: Disscusionmentioning

confidence: 99%

Effects of Dietary Supplementation with Pumpkin oil (Cucurbita pepo) on Performance and Blood Fat of Broiler Chickens during Finisher Period

Hajati¹

2011

American Journal of Animal and Veterinary Sciences

View full text Add to dashboard Cite

Problem statement: Using most of antibiotic growth promoters as feed additives has been banned by the European Union due to cross-resistance against pathogens and residues in tissues; and scientists search for alternatives to antibiotics, two days. In this view, medicinal plants and essential oils extracted are becoming more important due to their antimicrobial and stimulating effects on animal digestive systems. Approach: This study was conducted to evaluate the use of Pumpkin oil in broiler nutrition as a natural growth promoting substance and its effect on abdominal and blood fat. A total of 144 one-day-old broiler chicks (Ross 308) were used in a completely randomized design with 3 treatments and 3 replicates. The experiment was conducted from 29-49 d of age. The main ingredients of diets included corn, soybean meal and wheat. The pumpkin oil levels added to the diets were 0.00 (control), 5.00 and 10.00 g kg −1 DM. Results: Pumpkin oil supplementation up to 5.00 g kg −1 DM diet had not significant effect on broilers performance, but supplementation in higher level (10.00 g kg −1 DM) significantly decreased broilers performance. Pumpkin oil supplementation decreased bird's mortality. Adding pumpkin oil had not any significant effect on abdominal fat pad and carcass composition, however cholesterol and triglyceride concentrations in plasma decreased at 49 days of age (P<0.05). Conclusion: Results of this study indicated that supplementation of diets with 5.00 g kg −1 DM pumpkin oil in corn-soybean meal-wheat based diet can be profitable because it reduced broiler chicken's mortality and it did not have any adverse effect on bird's performance.

show abstract

Section: Disscusionmentioning

confidence: 99%

Effects of Dietary Supplementation with Pumpkin oil (Cucurbita pepo) on Performance and Blood Fat of Broiler Chickens during Finisher Period

Hajati¹

2011

American Journal of Animal and Veterinary Sciences

View full text Add to dashboard Cite

show abstract

“…In this respect several investigations focused in the research of phytochemicals more safe with limited side effects in the treatment of obesity and its complications. Many epidemiological studies have found that the consumption of foods and drinks with high phenolic content is associated with the prevention of obesity (Choi et al 2007). In this respect, hydroxycinnamic acids which constitute a major class of phenolic acids that are widely available in seeds, fruits and vegetables, consumed as dietary phenolic compounds that play a vital role in the formation of commercially important intermediate molecules.…”

Section: Introductionmentioning

confidence: 99%

Anti-obesity and cardioprotective effects of cinnamic acid in high fat diet- induced obese rats

et al. 2014

View full text Add to dashboard Cite

Obesity is a chronic metabolic disorder that is associated with numerous diseases including hyperlipidemia, diabetes mellitus, hypertension, atherosclerosis, cardiovascular disease, and cancer. Cinnamic acid is a phytochemical compound having many biological effects and could be considered for the management of obesity. This study is aimed to assess the possible anti-obesity and cardioprotective properties of cinnamic acid (CA) in high fat diet-fed rats (HFD). Male Wistar rats were divided into 4 groups. They received normal diet, HFD diet, HFD supplemented with fluvastatin (2 mg/kg/day) or cinnamic acid (30 mg/kg/day) for 7 weeks. The results showed an increase in body weight of HFD rats bỹ 27 % as compared to control group. Moreover, serum lipase activity underwent a significant rise by 103 % which led to an increase in the levels of total cholesterol (T-Ch), triglycerides (TG), LDL-cholesterol in serum of untreated HFD-fed rats. Furthermore, the concentration of leptin and angiotensinconverting enzyme (ACE) activity exhibited remarkable increases in serum of HFD-fed rats as compared to controls. Whereas, the administration of CA to HFD-fed rats improved the body weight gain and serum lipid profile and reverted back near to normal the activities of lipase and ACE. In addition, the echocardiography evidenced that CA is able to protect the aorta and aortic arch and avoided vasoconstriction by increasing their diameters and improved liver steatosis and kidney indices of toxicity. Overall, these results suggest that cinnamic acid exerts anti-obesity and antihypertensive effects through inhibition of lipid digestive enzymes and ACE.

show abstract

“…Obesity results from an imbalance between energy intake and energy expenditure, and is characterized by increased fat accumulation in adipose tissue and elevated lipid concentrations in blood (Prins and O'Rahilly 1997;Devlin et al 2000;Fujioka 2002). Enlarged fat mass is associated with an increase in number and size of adipocytes differentiated from preadipocytes in adipose tissue (Choi et al 2007). Differentiated adipocytes store free fatty acids (FFAs) in the form of triglyceride (TG) in cytoplasm, a synthesizing process known as lipogenesis.…”

Section: Introductionmentioning

confidence: 99%

Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice

et al. 2010

View full text Add to dashboard Cite

The present study examined the antiobesity effect and mechanism of action of Korean white ginseng extracts (KGE) using high-fat diet (HFD)-induced obese mice. Mice were fed a low-fat diet (LFD), HFD or HFD containing 0.8 and 1.6% (w/ w) KGE diet (HFD ? 0.8KGE and HFD ? 1.6KGE) for 8 weeks. We also examined the effects of KGE on plasma triglyceride (TG) elevation in mice administrated with oral lipid emulsion. Body weight gain and white adipose tissue (WAT) weight were significantly decreased in the HFD ? 1.6KGE group, compared with the HFD group. The plasma TG levels were also significantly reduced in both HFD ? 0.8KGE and HFD ? 1.6KGE groups, while leptin levels were significantly decreased in only the HFD ? 1.6KGE group, compared with the HFD group. The HFD ? 1.6KGE group showed significantly lower mRNA levels of lipogenesis-related genes, including peroxisome proliferator-activated receptorc2 (PPARc2), sterol regulatory element binding protein-1c (SREBP-1c), lipoprotein lipase (LPL), fatty acid synthase (FAS) and diacylglycerol acyltransferase 1 (DGAT1), compared with the HFD group. In addition, a dose of 1000 mg/kg KGE inhibited the elevation of plasma TG levels compared with mice given the lipid emulsion alone. These results suggest that the anti-obesity effects of KGE may be elicited by regulating expression of lipogenesis-related genes in WAT and by delaying intestinal fat absorption.

show abstract

A water-soluble extract from Cucurbita moschata shows anti-obesity effects by controlling lipid metabolism in a high fat diet-induced obesity mouse model

Cited by 89 publications

References 12 publications

Effects of Dietary Supplementation with Pumpkin oil (Cucurbita pepo) on Performance and Blood Fat of Broiler Chickens during Finisher Period

Effects of Dietary Supplementation with Pumpkin oil (Cucurbita pepo) on Performance and Blood Fat of Broiler Chickens during Finisher Period

Anti-obesity and cardioprotective effects of cinnamic acid in high fat diet- induced obese rats

Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice

Contact Info

Product

Resources

About