A water-soluble silver(I) formulation as an effective disinfectant of contact lenses cases

Chrysouli, M.P.; Banti, Christina N.; Milionis, Ilias; Koumasi, D.; Raptopoulou, Catherine P.; Psycharis, Vassilis; Sainis, Ioannis; Hadjikakou, Sotiris K.

doi:10.1016/j.msec.2018.08.061

Cited by 14 publications

(84 citation statements)

References 38 publications

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“…The effects of PenAg or PenNa on the growth of microbial strains: This study was performed according standard procedure, which is also described elsewhere [8][9][10][11][12]30]. Briefly, the bacterial strains were streaked onto in trypticase soy agar.…”

Section: Methodsmentioning

confidence: 99%

“…The growth was assessed after incubation for 20 h. The minimal inhibitory concentration (MIC) was determined as the concentration of the compound which inhibits the visible growth of the bacterium being investigated. The optical density of the solution at 620 nm compared to the concentrations graph led to the MIC determination [8][9][10][11][12]30].…”

Section: Methodsmentioning

confidence: 99%

“…Minimum bactericidal concentration testing: This study was performed according standard procedure which is also described elsewhere [8][9][10][11][12]31]. Bacteria were initially cultivated in the presence of PenAg in broth culture for 20 h. The MBC values were determined in duplicate, by subculturing 4 µL of the broth an agar plate [8][9][10][11][12]31]. Colony growth suggests non bactericidal activity of a metallodrug.…”

Section: Methodsmentioning

confidence: 99%

“…Colony growth suggests non bactericidal activity of a metallodrug. Thus, minimum bactericidal concentration was then defined as the lowest concentration at which a tested compound inhibited the microbe's growth completely [8][9][10][11][12]31].…”

Section: Methodsmentioning

confidence: 99%

“…The conjugation of metals with drugs (CoMeDs) is a new research area for the discovery of new synergistic therapeutic modalities. CoMeDs combines two different agents, such as silver(I) with penicillin to create new agents with new properties from the superimposition of those initially possessed by the constituents [6][7][8][9][10][11][12]. Although the term "conjugate" is more properly used for polymer-drugs or dendrimer-drug conjugates where nanoparticles are formed, recently, the term CoMeD has also been used to emphasize the synergistic effect of the coordination of a metal with drugs [13,14].…”

Section: Introductionmentioning

confidence: 99%

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Conjugation of Penicillin-G with Silver(I) Ions Expands Its Antimicrobial Activity against Gram Negative Bacteria

et al. 2020

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Conjugation of penicillin G (PenH) with silver(I) ions forms a new CoMeD (conjugate of metal with a drug) with formula [Ag(pen)(CH3OH)]2 (PenAg). PenAg was characterized by a plethora of physical and spectroscopic techniques, which include in the solid state m.p.; elemental analysis; X-ray fluorescence (XRF) spectroscopy; scanning electron microscopy (SEM); energy-dispersive X-ray spectroscopy (EDX); FT-IR; and in solution: attenuated total reflection spectroscopy (FT-IR-ATR), UV–Vis, 1H NMR, and atomic absorption (AA). The structure of PenAg was determined by NMR spectroscopy. Silver(I) ions coordinate to the carboxylic group of PenH, while secondary intra-molecular interactions are developed through (i) the nitrogen atom of the amide group in MeOD-d4 or (ii) the sulfur atom in the thietane ring in deuterated dimethyl sulfoxide DMSO-d6. The antibacterial activities of PenAg and the sodium salt of penicillin (PenNa) (the formulation which is clinically used) against Gram positive (Staphylococcus epidermidis (S. epidermidis) and Staphylococcus aureus (S. aureus)) and Gram negative (Pseudomonas aeruginosa (P. aeuroginosa PAO1)) bacteria were evaluated by the means of minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and inhibition zone (IZ). PenAg inhibits the growth of the Gram negative bacterial strain P. aeuroginosa with a MIC value of 23.00 ± 2.29 μM, in contrast to PenNa, which shows no such activity (>2 mM). The corresponding antimicrobial activities of PenAg against the Gram positive bacteria S. epidermidis and S. aureus are even better than those of PenNa. Moreover, PenAg exhibits no in vivo toxicity against Artemia salina at concentration up to 300 μΜ. The wide therapeutic window and the low toxicity, make PenAg a possible candidate for the development of a new antibiotic.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Conjugation of Penicillin-G with Silver(I) Ions Expands Its Antimicrobial Activity against Gram Negative Bacteria

et al. 2020

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Assessment of the biological effect of metal ions and their complexes using Allium cepa and Artemia salina assays: a possible environmental implementation of biological inorganic chemistry

2022

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The pollution of aquatic ecosystems due to the elevated concentration of a variety of contaminants, such as metal ions, poses a threat to humankind, as these ecosystems are in high relevance with human activities and survivability. The exposure in heavy metal ions is responsible for many severe chronic and pathogenic diseases and some types of cancer as well. Metal ions of the groups 11 (Cu, Ag, Au), 12 (Zn, Cd, Hg), 14 (Sn, Pb) and 15 (Sb, Bi) highly interfere with proteins leading to DNA damage and oxidative stress. While, the detection of these contaminants is mainly based on physicochemical analysis, the chemical determination, however, is deemed ineffective in some cases because of their complex nature. The development of biological models for the evaluation of the presence of metal ions is an attractive solution, which provides more insights regarding their effects. The present work critically reviews the reports published regarding the toxicity assessment of heavy metal ions through Allium cepa and Artemia salina assays. The in vivo toxicity of the agents is not only dose depended, but it is also strongly affected by their ligand type. However, there is no comprehensive study which compares the biological effect of chemical agents against Allium cepa and Artemia salina. Reports that include metal ions and complexes interaction with either Allium cepa or Artemia salina bio-indicators are included in the review. Graphical abstract

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pHEMA@AGMNA-1: A novel material for the development of antibacterial contact lens

Rossos

Banti

Kalampounias

et al. 2020

Materials Science and Engineering: C

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A water-soluble silver(I) formulation as an effective disinfectant of contact lenses cases

Cited by 14 publications

References 38 publications

Conjugation of Penicillin-G with Silver(I) Ions Expands Its Antimicrobial Activity against Gram Negative Bacteria

Conjugation of Penicillin-G with Silver(I) Ions Expands Its Antimicrobial Activity against Gram Negative Bacteria

Assessment of the biological effect of metal ions and their complexes using Allium cepa and Artemia salina assays: a possible environmental implementation of biological inorganic chemistry

pHEMA@AGMNA-1: A novel material for the development of antibacterial contact lens

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