A water-soluble thiophene-croconaine dye with a high molar extinction coefficient for NIR fluorescence imaging-guided synergistic photothermal/photodynamic therapy of cancer

Pang, E; Zhao, Shaojing; Yang, Ke; Li, Baoling; Tan, Qiuxia; Tan, Siyi; Lan, Minhuan; Wang, Benhua; Song, Xiangzhi

doi:10.1039/d2tb01772e

Cited by 8 publications

(4 citation statements)

References 28 publications

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“…Of note, it has been found that croconium dye not only has a similar photothermal effect to gold nanomaterials, but also possesses the advantages of being biodegradable and not lingering in the blood circulation. [ 162 ] Inspired by this, a multifunctional nanocarrier called PhotoPhage was developed by Gassensmith and co‐workers (Figure 5B). [ 159 ] The PhotoPhage was explored by modifying croconium dye on phage Qβ.…”

Section: Phage Nanovectors For Tumor Therapy Based On Different Pathwaysmentioning

confidence: 99%

Recent Progress in Phage‐Based Nanoplatforms for Tumor Therapy

Li,

Peng,

Feng

et al. 2023

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Nanodrug delivery systems have demonstrated a great potential for tumor therapy with the development of nanotechnology. Nonetheless, traditional drug delivery systems are faced with issues such as complex synthetic procedures, low reproducibility, nonspecific distribution, impenetrability of biological barrier, systemic toxicity, etc. In recent years, phage‐based nanoplatforms have attracted increasing attention in tumor treatment for their regular structure, fantastic carrying property, high transduction efficiency and biosafety. Notably, therapeutic or targeting peptides can be expressed on the surface of the phages through phage display technology, enabling the phage vectors to possess multifunctions. As a result, the drug delivery efficiency on tumor will be vastly improved, thereby enhancing the therapeutic efficacy while reducing the side effects on normal tissues. Moreover, phages can overcome the hindrance of biofilm barrier to elicit antitumor effects, which exhibit great advantages compared with traditional synthetic drug delivery systems. Herein, this review not only summarizes the structure and biology of the phages, but also presents their potential as prominent nanoplatforms against tumor in different pathways to inspire the development of effective nanomedicine.

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Section: Phage Nanovectors For Tumor Therapy Based On Different Pathwaysmentioning

confidence: 99%

Recent Progress in Phage‐Based Nanoplatforms for Tumor Therapy

Li,

Peng,

Feng

et al. 2023

Small

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“…Photodynamic therapy (PDT), utilizing reactive oxygen species (ROS) including singlet oxygen ( 1 O 2 ), [1][2][3][4] superoxide anion free radical (O 2 −• ), [5][6][7][8][9][10] hydroxyl radical (OH•), [11][12][13][14] and so on generated by photosensitizers (PSs) to oxidize cancer cells, holds tremendous promise for cancer treatment owing to its high selectivity, minimal invasiveness, and low systemic cytotoxicity. [15][16][17][18] Currently, most commercial PSs applied in clinics mainly rely DOI: 10.1002/adom.202302834 on the high 1 O 2 generation to achieve tumor ablation, for instance, Ce6, ICG, MB, etc.…”

Section: Introductionmentioning

confidence: 99%

Constructing Singlet Oxygen “Slow Release” Platform to Optimize the Performance of Commercial Photosensitizers

Ni,

Wang,

et al. 2024

Advanced Optical Materials

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Commercial photosensitizers (PSs) present great potential in the field of clinical photodynamic therapy (PDT) yet face a formidable challenge owing to the extremely short lifespan of singlet oxygen (1O2). Herein, the 1O2 slow‐release “platform” is proposed based on an anthracene‐groups functionalized D‐π‐A system (AIC), which can capture and slowly release 1O2 produced by commercial PSs. Meanwhile, the reversible chemical process between AIC and 1O2 is demonstrated by a series of optical experiments and high‐resolution mass spectrum. Remarkably, by virtue of 1O2 slow‐release “platform”, the sustaining mitochondrial autophagy and cell apoptosis still take place when the laser is cut off with a short period of irradiation, reducing the side effect of sustained irradiation. In general, the construction of 1O2 slow‐release platform opens up exciting opportunities for improving the PDT effect of commercial PSs.

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“…Photothermal therapy (PTT) has attracted widespread attention due to its high selectivity, non-invasiveness, and oxygen-independent features. , A precise diagnosis and therapy of tumors can be achieved simultaneously by NIR-II fluorescence and PA imaging-guided PTT, along with the evaluation of the therapeutic efficacy in real-time. Ideal phototherapeutics are characterized by strong NIR absorption/fluorescence and high photothermal conversion efficiency (PCE). , Metal-based nanostructures usually exhibit high PCE in the NIR region due to their strong plasma resonance.…”

Section: Introductionmentioning

confidence: 99%

Aggregation-Enhanced Photophysical Performance of D-π-A Structured Hemicyanine for NIR-II Fluorescent and Photoacoustic Imaging-Guided Photothermal Therapy

Pang

Zhao

et al. 2023

Chemical & Biomedical Imaging

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Near-infrared (NIR)-II fluorescence and photoacoustic (PA) dual-model imaging-guided photothermal therapy (PTT) can precisely diagnose and treat tumors and evaluate the therapeutic efficacy in real-time. Herein, we utilized a donor-π-acceptor (D-π-A) structured hemicyanine dye (named M1) with a large conjugated structure and strong intramolecular charge transfer effect and demonstrated that the aggregation of M1 could significantly enhance its photophysical performance by improving its photostability and photothermal conversion capability as compared with M1 in a single molecular state. Furthermore, we prepared water-dispersible NIR-II fluorescent nanoparticles (M1 NPs) by wrapping M1 with DSPE-PEG2000-NH2. The obtained M1 NPs exhibit strong NIR-I absorption and NIR-II fluorescence with their maxima at 734 and 1040 nm, respectively, with a fluorescence quantum yield of 2.84%. Moreover, M1 NPs also exhibit excellent biocompatibility, good photostability, and high photothermal conversion efficiency of 77.5%. In vitro and in vivo experiments reveal that M1 NPs can effectively image tumors through NIR-II fluorescence and PA signals, inhibit DNA replication, trigger cytoskeleton collapse, and eventually induce tumor cell apoptosis under 808 nm laser irradiation. Based on these outstanding properties, the application of M1 NPs in PA and NIR-II fluorescence imaging-guided PTT of tumors is demonstrated.

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A water-soluble thiophene-croconaine dye with a high molar extinction coefficient for NIR fluorescence imaging-guided synergistic photothermal/photodynamic therapy of cancer

Abstract: Phototherapeutic agents with near-infrared (NIR) fluorescence, high reactive oxygen species (ROS) generation and high photothermal conversion efficiency (PCE) are highly desirable for use in cancer therapy. Herein, a water-soluble NIR...

Cited by 8 publications

References 28 publications

Recent Progress in Phage‐Based Nanoplatforms for Tumor Therapy

Recent Progress in Phage‐Based Nanoplatforms for Tumor Therapy

Constructing Singlet Oxygen “Slow Release” Platform to Optimize the Performance of Commercial Photosensitizers

Aggregation-Enhanced Photophysical Performance of D-π-A Structured Hemicyanine for NIR-II Fluorescent and Photoacoustic Imaging-Guided Photothermal Therapy

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