A wave of IP3 production accompanies the fertilization Ca2+ wave in the egg of the frog, Xenopus laevis: theoretical and experimental support

Wagner, John; Fall, Christopher P.; Hong, Feng; Sims, Christopher E.; Allbritton, Nancy L.; Fontanilla, Ray A; Moraru, Ion I.; Loew, Leslie M.; Nuccitelli, Richard

doi:10.1016/j.ceca.2003.10.009

Cited by 83 publications

(162 citation statements)

References 70 publications

Supporting

Mentioning

154

Contrasting

Order By: Relevance

“…Here, only the PH domain-YFP fusion protein shows movements but the FRET changes are very similar to those described under a. These examples are derived from analysis of COS-7 cells at the plasma membrane after agonist stimulation, increased Ca 2+ levels can trigger a secondary wave of PLC activation both at the plasma membrane or other internal membranes where PLC enzymes and PtdIns(4,5)P 2 is located [96]. It has also been convincingly demonstrated that InsP 3 -mediated Ca 2+ release at sites where the ER and mitochondria are in close juxtaposition (also called mitochondria-associated membranes, MEM) has a unique impact on mitochondrial Ca 2+ uptake [29,79].…”

Section: Lipid-binding Domains As Inhibitors Of Inositide-based Regulmentioning

confidence: 69%

Visualization and manipulation of phosphoinositide dynamics in live cells using engineered protein domains

Várnai

Balla

2007

Pflugers Arch - Eur J Physiol

View full text Add to dashboard Cite

There is hardly a membrane-associated molecular event that is not regulated by phosphoinositides, a minor but critically important class of phospholipids of cellular membranes. The rapid formation, elimination, and conversion of these lipids in specific membrane compartments are ensured by a wealthy number of inositol lipid kinases and phosphatases with unique localization and regulatory properties. The existence of multiple inositol lipid pools have been indicated by metabolic labeling studies, but the level of functional compartmentalization revealed by the identification of numerous protein effectors acted upon by phosphoinositides could not have been foreseen. The changing perception of inositides from just serving as lipid precursors of second messengers to becoming highly dynamic local membrane-bound regulators poses new challenges concerning the detection of their rapid localized changes. Moreover, it is increasingly evident that manipulation of lipids in highly defined compartments would be a highly superior approach to soaking the cells with a particular phosphoinositide when studying the local regulation of the lipid on any effectors. In this review, we will summarize our efforts to improve our tools in studying phosphoinositide dynamics and discuss our views on the values of these methods compared to other options currently used or being explored.

show abstract

Section: Lipid-binding Domains As Inhibitors Of Inositide-based Regulmentioning

confidence: 69%

Visualization and manipulation of phosphoinositide dynamics in live cells using engineered protein domains

Várnai

Balla

2007

Pflugers Arch - Eur J Physiol

View full text Add to dashboard Cite

show abstract

“…The Ca 2þ wave is due to Ca 2þ release from intracellular stores through the IP 3 receptor (IP 3 R), since it is inhibited by blocking IP 3 -dependent Ca 2þ release or PIP2 hydrolysis (Larabell and Nuccitelli, 1992;Nuccitelli et al, 1993;Runft et al, 1999). Moreover, a wave of IP 3 has been proposed to precede the Ca 2þ release wave in eggs at fertilization (Wagner et al, 2004). Therefore, the Ca 2þ signal at fertilization is biphasic with a slow rising phase that represents the sweeping Ca 2þ wave, followed by a sustained plateau.…”

Section: Spatial and Temporal Dynamics Of Ca 2r Signals During Maturamentioning

confidence: 99%

Ca²⁺ signaling differentiation during oocyte maturation

Machaca

2007

Journal Cellular Physiology

View full text Add to dashboard Cite

Oocyte maturation is an essential cellular differentiation pathway that prepares the egg for activation at fertilization leading to the initiation of embryogenesis. An integral attribute of oocyte maturation is the remodeling of Ca 2þ signaling pathways endowing the egg with the capacity to produce a specialized Ca 2þ transient at fertilization that is necessary and sufficient for egg activation. Consequently, mechanistic elucidation of Ca 2þ signaling differentiation during oocyte maturation is fundamental to our understanding of egg activation, and offers a glimpse into Ca 2þ signaling regulation during the cell cycle.

show abstract

“…Here we have considered only fixed IP3 as a simplification. IP3 is certainly dynamic, its production may also be Ca 2+ sensitive, and such a system has been modeled in other cells Wagner et al, 2004). The parameters are described in Table 1.…”

Section: The Modelmentioning

confidence: 99%

An intracellular Ca2+ subsystem as a biologically plausible source of intrinsic conditional bistability in a network model of working memory

Fall

Rinzel

2006

J Comput Neurosci

View full text Add to dashboard Cite

We have developed a firing rate network model for working memory that combines Mexican-hat-like synaptic coupling with intrinsic or cellular dynamics that are conditionally bistable. While our approach is in the spirit of Camperi and Wang (1998) we include a specific and plausible mechanism for the cellular bistability. Modulatory neurotransmitters are known to activate second messenger signaling systems, and our model includes an intracellular Ca(2+) handling subsystem whose dynamics depend upon the level of the second messenger inositol 1,4,5 trisphosphate (IP3). This Ca(2+) subsystem endows individual units with conditional intrinsic bistability for a range of IP3. The full "hybrid" network sustains IP3-dependent persistent ("bump") activity in response to a brief transient stimulus. The bump response in our hybrid model, like that of Camperi-Wang, is resistant to noise-- its position does not drift with time.

show abstract

A wave of IP3 production accompanies the fertilization Ca2+ wave in the egg of the frog, Xenopus laevis: theoretical and experimental support

Cited by 83 publications

References 70 publications

Visualization and manipulation of phosphoinositide dynamics in live cells using engineered protein domains

Visualization and manipulation of phosphoinositide dynamics in live cells using engineered protein domains

Ca²⁺ signaling differentiation during oocyte maturation

An intracellular Ca2+ subsystem as a biologically plausible source of intrinsic conditional bistability in a network model of working memory

Contact Info

Product

Resources

About

A wave of IP3 production accompanies the fertilization Ca2+ wave in the egg of the frog, Xenopus laevis: theoretical and experimental support

Cited by 83 publications

References 70 publications

Visualization and manipulation of phosphoinositide dynamics in live cells using engineered protein domains

Visualization and manipulation of phosphoinositide dynamics in live cells using engineered protein domains

Ca2+ signaling differentiation during oocyte maturation

An intracellular Ca2+ subsystem as a biologically plausible source of intrinsic conditional bistability in a network model of working memory

Contact Info

Product

Resources

About

Ca²⁺ signaling differentiation during oocyte maturation