PM2.5 in the atmosphere causes severe air pollution and dramatically affects the normal production and lives of residents. The real-time monitoring of PM2.5 concentrations has important practical significance for the construction of ecological civilization. The mainstream PM2.5 concentration prediction algorithms based on electrochemical sensors have some disadvantages, such as high economic cost, high labor cost, time delay, and more. To this end, we propose a simple and effective PM2.5 concentration prediction algorithm based on image perception. Specifically, the proposed method develops a natural scene statistical prior to estimating the saturation loss caused by the ’haze’ formed by PM2.5. After extracting the prior features, this paper uses the feedforward neural network to achieve the mapping function from the proposed prior features to the PM2.5 concentration values. Experiments constructed on the public Air Quality Image Dataset (AQID) show the superiority of our proposed PM2.5 concentration measurement method compared to state-of-the-art related PM2.5 concentration monitoring methods.