A Wearable Iron-Based Implant as an Intramedullary Nail in Tibial Shaft Fracture of Sheep

Abstract

A stable repaired fracture is the key factor responsible for the recovery of a damaged bone. The iron-based implant is one of the biodegradable metals that have been proven safe as a fracture fixation device. The objective of our experimental approach was to examine the potential of the iron-based implant as a biodegradable metal in tibia shaft fracture in sheep chronically. The samples used for this experiment were iron-based and stainless steel implants. Each had a diameter of 5 mm. These samples were analyzed through 3 phases which are material characterization, in vitro and in vivo examination. The samples were examined using a scanning electron microscope with energy dispersive spectrometer and X-ray diffraction. Based on the analysis carried out, the samples contained 90,02% and 60,81% Fe for iron-based implant and stainless implant, respectively. Both implants maintained high viability when being in contact with calf pulmonary artery endothelial cells, indicating that both implants had a minimum response to the cell in a hemocytometer and methyl tetrazolium (MTT) assay. The systemic effect of the implants was observed using hematology and blood chemistry examination. Data collection also shows that both implants also had a minimum response to the erythrocytes, leucocytes, blood chemistry, and blood mineral during the period of observation. Therefore, it could be concluded that the iron-based implant is tolerable for a period of 9 months. It also has the potential to be used as a biodegradable orthopedic implant.

Refinement in Post-Operative Care for Orthopaedic Models: Implementing a Sheep Walking Cast (SWC) for Effective Tibial Fracture Management

“…Imperfect alignment can lead to uneven stress and wear on the joint surfaces, often associated with significant knee pain or further arthrosis. Surgical treatment can be performed through intramedullary nailing [12,13], external fixation [14], or plate fixation [15], and the specific method used depends on the type and location of the tibial fracture. Plate fixation offers excellent stability and alignment control, making it suitable for a wide range of fracture types including complex and comminuted fractures, and is therefore often used [16].…”

Calcium Phosphate Incorporated Bacterial Cellulose-Polyvinylpyrrolidone Based Hydrogel Scaffold: Structural Property and Cell Viability Study for Bone Regeneration Application

“…Additionally, the devices used for orthopedic trauma treatment had a market of 5.7 billion in 2013, and has been predicted to reach about 7.2% of the entire global market by 2020 [8]. The current bone fracture fixation treatments include the application of stainless steel, titanium, and titanium alloys [9]. However, these metallic implants are non-degradable and thus need to be surgically removed from the body [8,10].…”