A Weight‐Loss Diet Including Coffee‐Derived Mannooligosaccharides Enhances Adipose Tissue Loss in Overweight Men but Not Women

Abstract

Mannooligosaccharides (MOS), extracted from coffee, have been shown to promote a decrease in body fat when consumed as part of free-living, weight-maintaining diets. Our objective was to determine if MOS consumption (4 g/day), in conjunction with a weight-loss diet, would lead to greater reductions in adipose tissue compartments than placebo. We conducted a double-blind, placebo-controlled weight-loss study in which 60 overweight men and women consumed study beverages and received weekly group counseling for 12 weeks. Weight and blood pressure were measured weekly, and adipose tissue distribution was assessed at baseline and at end point using magnetic resonance imaging. A total of 54 subjects completed the study. Men consuming the MOS beverage had greater loss of body weight than men consuming the Placebo beverage (−6.0 ± 0.6% vs. −2.3 ± 0.5%, respectively, P < 0.05). Men consuming the MOS beverage also had reductions in total body volume (P < 0.0001), total (P < 0.0001), subcutaneous (P < 0.0001), and visceral (P < 0.05) adipose tissue that were greater than changes observed in those consuming the Placebo beverage. In women, changes in body weight and adipose tissue compartments were not different between groups. Adding coffee-derived MOS to a weight-loss diet enhanced both weight and adipose tissue losses in men, suggesting a potential functional use of MOS for weight management and improvement in adipose tissue distribution. More studies are needed to investigate the apparent gender difference in response to MOS consumption.

Effectiveness of weight loss interventions – is there a difference between men and women: a systematic review

“…Significant within sex differences were reported in 28 studies , and of these, 17 compared differences in weight loss between intervention groups and four reported differences for each intervention but did not compare interventions . Within the first 17 studies, the following comparisons were made (24 interventions within 17 studies): diet plus exercise vs. minimal intervention ( n = 6); diet plus exercise vs. control ( n = 2); diet plus exercise vs. diet plus exercise ( n = 3); diet plus exercise vs. diet ( n = 1); diet vs. control ( n = 1); diet vs. minimal intervention ( n = 1), diet vs. diet ( n = 3); diet plus meal replacements vs. diet ( n = 2); exercise vs. control ( n = 1), diet vs. placebo ( n = 2) and supplement vs. placebo ( n = 2).…”

“…Eighteen studies (31%) were published before 1999 (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43) with the remaining (69%) published from 2000 onwards . Of the 58 studies, 32 (55%) were conducted in the USA (26,27,29,30,(32)(33)(34)(35)(36)(37)39,41,(43)(44)(45)(49)(50)(51)(52)54,57,60,62,65,72,75,76,(78)(79)(80)83,84); 7 in Australia (47,…”

“…diet vs. diet). Of these, 10 compared dietary interventions (27,35,46,53,58,61,72,78,82,83), 2 compared PA (48,49) and 7 compared combinations of diet and PA interventions (31,45,50,62,63,65,79). Two studies compared different interventions (i.e.…”

Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects

“…Coffee is of interest as a possible nutraceutical for weight loss because caffeine is a well known stimulant, and an epidemiology study found that coffee consumption resulted in less weight gain in obese men over an 18-month period 5. A polysaccharide ingredient in coffee caused weight reduction when added to the diet of obese men but was not effective for women 6. Freeze-dried coffee was found to cause weight loss when given to rats.…”

Supplements for Weight Loss

“…There is abundant literature to support the benefit of coffee, which seems to facilitate weight loss and prevent and/or improve a wide variety of chronic illnesses 2 – 5 . Evidence is accumulating from animal studies regarding the use of green coffee bean extract (GCBE) as a weight loss supplement.…”