A Whole Blood Immunoassay Using Gold Nanoshells

Hirsch, Leon; Jackson, J. B.; Lee, A; Halas, Naomi J.; West, Jennifer L.

doi:10.1021/ac0262210

Cited by 653 publications

(455 citation statements)

References 25 publications

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“…An early demonstration of photothermal therapy was reported by Halas et al [160]. Using nanoshells with a 110 nm silica core diameter and a 10 nm Au shell, the authors reported significant reduction of human breast carcinoma epithelial cells (SK-Br-3) both in vitro and in a mouse model.…”

Section: Photothermal Ablation (Pta) Therapymentioning

confidence: 99%

“…Another parameter involved in heat generation is the power of the operating laser as well as whether the laser is run in continuous wave (CW) or pulsed wave (PW) mode when interacting with nanoparticles [150,[159][160][161][162][163]. While there is still some debate as to which mode is best, pulsed mode is generally considered more efficient than continuous mode for heating nanoparticles in photothermal applications [150,[164][165][166][167][168].…”

Section: The Influence Of Laser Mode and Powermentioning

confidence: 99%

“…Typically penetration in the range of 1-20 mm is sufficient for the ablation of cancer cells that are near the surface of the skin [160,191,193,204]. However, it has been reported that depths of 50-80 mm have been achieved [186,205].…”

Section: Photothermal Ablation (Pta) Therapymentioning

confidence: 99%

“…SERS based immunoassays utilizing noble metal substrates are rapidly becoming the preferred choice for detection of biological markers [73,119,128,160,[312][313][314]. They are considered to have many advantages over traditional enzyme linked immunosorbent assays (ELISAS) which are considered tedious, time consuming, and rely on the use of toxic and unstable fluorescent dyes and quantum dots (QDs) [282,[315][316][317].…”

Section: Sers Immunoassaysmentioning

confidence: 99%

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Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

2016

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By electrodeposition and galvanic replacement reaction, we developed a facile, time-saving, cost-effective, and environmentally friendly, two-step synthesis route to obtain a controllable cobalt oxide/Au hierarchically nanostructured electrode for glucose sensing. The nanomaterials were characterized by transmission electron microscopy, scanning electron microscopy, Raman spectroscopy, energy-dispersive spectrometry, and X-ray photoelectron spectroscopy, meanwhile, the sensing performance was investigated by cyclic voltammetry and amperometric response. The results revealed that this novel electrode exhibited excellent electrocatalytic performance toward glucose oxidation, with a wide double-linear range from 0.2 μM to 20 mM and a low detection limit of 0.1 μM based on a signal-to-noise ratio of 3, which was mainly attributed to the ability of loading a small amount of Au with good electron conductivity on the surface of cobalt oxide nanosheets with large active surface area and synergistic electrocatalytic activity of Au and cobalt oxide toward glucose electrooxidation. This facile, sensitive, and selective glucose sensor is also proven to be suitable for the detection of glucose in human serum.

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Section: Photothermal Ablation (Pta) Therapymentioning

confidence: 99%

Section: The Influence Of Laser Mode and Powermentioning

confidence: 99%

Section: Photothermal Ablation (Pta) Therapymentioning

confidence: 99%

Section: Sers Immunoassaysmentioning

confidence: 99%

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Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

2016

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“…From a practical perspective, the tunable optical properties of nanostructures make it possible to use these materials in surfaceenhanced spectroscopy, [10][11][12][13][14] optical filters, 15,16 plasmonic devices, [17][18][19][20] and sensors. [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35] Until recently, there were only limited methods for the synthesis of monodisperse, nonspherical noble metal nanoparticles, which meant that the practical applications of these particles were limited. Recent advances in controlled syntheses of spheres, 36,37 rods, [38][39][40] triangular prisms, [41][42][43] disks, [44][45][46] cubes, 47 and branched nanocrystals 48 have improved both the fundamental understanding and practical use of these nanoparticles for sensing and spectroscopic devices.…”

Section: Introductionmentioning

confidence: 99%

Solution-Phase, Triangular Ag Nanotriangles Fabricated by Nanosphere Lithography

Haes¹,

Zhao²,

Zou³

et al. 2005

J. Phys. Chem. B

112

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A novel method to produce solution-phase triangular silver nanoparticles is presented. Ag nanoparticles are prepared by nanosphere lithography and are subsequently released into solution. The resulting nanoparticles are asymmetrically functionalized to produce either single isolated nanoparticles or dimer pairs. The structural and optical properties of Ag nanoparticles have been characterized. Mie theory and the Discrete Dipole Approximation method (DDA) have been used to model and interpret the optical properties of the released Ag nanoparticles.

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Nanophotonics for Biotechnology and Nanomedicine

Prasad¹

2004

Nanophotonics

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Nanophotonics broadly impacts biomedical research and technology for studying the fundamentals of interactions and dynamics at single cell/molecule level, as well as for applications to light-guided and light-activated therapy using nanomedicine. Nanomedicine is an emerging field that deals with utilization of nanoparticles in the development of new methods of minimally invasive diagnostics for early detection of diseases, as well as for facilitating targeted drug delivery, effectiveness of therapy, and real-time monitoring of drug action. This chapter illustrates a broad range of potential applications by providing some demonstrative examples. A fundamental understanding of drug-cell interactions, based on molecular changes at the single-cell level induced by a pre-onset state of a disease, can provide a basis for molecular recognition-based "personalized" therapeutic approaches to treat diseases. Nanophotonics enables one to use optical techniques for tracking of drug intake, elucidating its cellular pathway and monitoring subsequent intracellular interactions. For this purpose, bioimaging, biosensing, and single-cell biofunction studies, using optical probes, are proving to be extremely valuable.In the area of nanomedicine-based molecular recognition of diseases, light-guided and light-activated therapies provide a major advancement. Nanoparticles containing optical probes, light-activated therapeutic agents, and specific carrier groups that can direct the nanoparticles to the diseased cells or tissues provide targeted drug delivery, with an opportunity for real-time monitoring of drug efficacy. This chapter provides some examples of both optical diagnostics and light-based therapy.Section 13.1 illustrates the usage of near-field microscopy, a technique already discussed in Chapter 3, for bioimaging of microbes and biostructures that are of dimensions considerably less than the wavelengths of light used. Section 13.2 provides a general description of nanophotonic approaches for optical diagnostics and light-activated and guided therapy. Section 13.3 presents semiconductor quantum dots for bioimaging. These quantum dots and their size-dependent optical properties have been discussed in Chapter 4. Section 13.4 covers up-converting nanoparticles for bioimaging. These nanoparticles, containing rare-earth ions, absorb in the IR and emit in the visible spectral range and have been discussed in Chapter 6. Merits of these inorganic emitters over the organic fluorophores are also described in their respective sections.

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A Whole Blood Immunoassay Using Gold Nanoshells

Cited by 653 publications

References 25 publications

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

Controllable Cobalt Oxide/Au Hierarchically Nanostructured Electrode for Nonenzymatic Glucose Sensing

Solution-Phase, Triangular Ag Nanotriangles Fabricated by Nanosphere Lithography

Nanophotonics for Biotechnology and Nanomedicine

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